Nonsynaptic noradrenaline release in neuro-immune responses

E. Vízi, I. J. Elenkov

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Evidence has recently been obtained that the branches of the autonomic nervous system, mainly, the sympathetic [25], regulate cytokine production. Not only the primary (thymus, bone marrow) and secondary (spleen, tonsils, and lymph nodes) lymphoid organs, but also many other tissues are involved in immune responses and are heavily influenced by noradrenaline (NA) derived from varicose axon terminals of the sympathetic nervous system [25, 100]. Besides NA released from nonsynaptic varicosities of noradrenergic terminals [92], circulating catecholamines (adrenaline, dopamine, NA) are also able to influence immune responses, the production of pro- and anti-inflammatory cytokines by different immune cells. The sympathetic nervous system (catecholamines) and the hypothalamic-pituitary-adrenal (HPA) axis (cortisol) are the major integrative and regulatory components of different immune responses. In our laboratory convincing evidence has been obtained that NA released non-synaptically [90, 92] from sympathetic axon terminals and enhanced in concentration in the close proximity of immune cells is able to inhibit production of proinflammatory (TNF-α, IFN-γ, IL-12, IL-1) and increase antiinflammatory cytokines (IL-10) in response to LPS [25, 91], indicating a fine-tuning control of the production of TNF-α and other cytokines by sympathetic innervation under stressful conditions. This effects are mediated via β2-adrenoceptors expressed on immune cells and coupled to cAMP levels.

Original languageEnglish
Pages (from-to)229-244
Number of pages16
JournalActa Biologica Hungarica
Volume53
Issue number1-2
DOIs
Publication statusPublished - 2002

Fingerprint

nervous system
norepinephrine
immune response
Norepinephrine
Neurology
cytokines
Cytokines
sympathetic nervous system
Sympathetic Nervous System
Presynaptic Terminals
catecholamines
axons
Catecholamines
Anti-Inflammatory Agents
autonomic nervous system
Thymus
tonsils
bone
Palatine Tonsil
interleukin-12

Keywords

  • Cytokines
  • Immune response
  • Nonsynaptic
  • Sympathetic outflow

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Nonsynaptic noradrenaline release in neuro-immune responses. / Vízi, E.; Elenkov, I. J.

In: Acta Biologica Hungarica, Vol. 53, No. 1-2, 2002, p. 229-244.

Research output: Contribution to journalArticle

Vízi, E. ; Elenkov, I. J. / Nonsynaptic noradrenaline release in neuro-immune responses. In: Acta Biologica Hungarica. 2002 ; Vol. 53, No. 1-2. pp. 229-244.
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