Nonsynaptic chemical transmission through nicotinic acetylcholine receptors

Balázs Lendvai, E. Vízi

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

This review attempts to organize the different aspects of nicotinic transmission in the context of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate in the nonsynaptic mode in the central nervous system despite their ligand-gated ion-channel nature, which would otherwise be better suited for fast synaptic transmission. This fast form of nonsynaptic transmission, most likely unique to nAChRs, represents a new avenue in the communication platforms of the brain. Cholinergic messages received by nAChRs, arriving at a later phase following synaptic activation, can interfere with dendritic signal integration. Nicotinic transmission plays a role in both neural plasticity and cellular learning processes, as well as in long-term changes in basic activity through fast activation, desensitization of receptors, and fluctuations of the steady-state levels of ACh. ACh release can contribute to plastic changes via activation of nAChRs in neurons and therefore plays a role in learning and memory in different brain regions. Assuming that nAChRs in human subjects are ready to receive long-lasting messages from the extracellular space because of their predominantly nonsynaptic distribution, they offer an ideal target for drug therapy at low, nontoxic drug levels.

Original languageEnglish
Pages (from-to)333-349
Number of pages17
JournalPhysiological Reviews
Volume88
Issue number2
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Nicotinic Receptors
Learning
Ligand-Gated Ion Channels
Neuronal Plasticity
Brain
Extracellular Space
Synaptic Transmission
Cholinergic Agents
Central Nervous System
Communication
Neurons
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physiology

Cite this

Nonsynaptic chemical transmission through nicotinic acetylcholine receptors. / Lendvai, Balázs; Vízi, E.

In: Physiological Reviews, Vol. 88, No. 2, 04.2008, p. 333-349.

Research output: Contribution to journalArticle

@article{5e5174b443dd4dbfa503764c938c83aa,
title = "Nonsynaptic chemical transmission through nicotinic acetylcholine receptors",
abstract = "This review attempts to organize the different aspects of nicotinic transmission in the context of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate in the nonsynaptic mode in the central nervous system despite their ligand-gated ion-channel nature, which would otherwise be better suited for fast synaptic transmission. This fast form of nonsynaptic transmission, most likely unique to nAChRs, represents a new avenue in the communication platforms of the brain. Cholinergic messages received by nAChRs, arriving at a later phase following synaptic activation, can interfere with dendritic signal integration. Nicotinic transmission plays a role in both neural plasticity and cellular learning processes, as well as in long-term changes in basic activity through fast activation, desensitization of receptors, and fluctuations of the steady-state levels of ACh. ACh release can contribute to plastic changes via activation of nAChRs in neurons and therefore plays a role in learning and memory in different brain regions. Assuming that nAChRs in human subjects are ready to receive long-lasting messages from the extracellular space because of their predominantly nonsynaptic distribution, they offer an ideal target for drug therapy at low, nontoxic drug levels.",
author = "Bal{\'a}zs Lendvai and E. V{\'i}zi",
year = "2008",
month = "4",
doi = "10.1152/physrev.00040.2006",
language = "English",
volume = "88",
pages = "333--349",
journal = "Physiological Reviews",
issn = "0031-9333",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - Nonsynaptic chemical transmission through nicotinic acetylcholine receptors

AU - Lendvai, Balázs

AU - Vízi, E.

PY - 2008/4

Y1 - 2008/4

N2 - This review attempts to organize the different aspects of nicotinic transmission in the context of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate in the nonsynaptic mode in the central nervous system despite their ligand-gated ion-channel nature, which would otherwise be better suited for fast synaptic transmission. This fast form of nonsynaptic transmission, most likely unique to nAChRs, represents a new avenue in the communication platforms of the brain. Cholinergic messages received by nAChRs, arriving at a later phase following synaptic activation, can interfere with dendritic signal integration. Nicotinic transmission plays a role in both neural plasticity and cellular learning processes, as well as in long-term changes in basic activity through fast activation, desensitization of receptors, and fluctuations of the steady-state levels of ACh. ACh release can contribute to plastic changes via activation of nAChRs in neurons and therefore plays a role in learning and memory in different brain regions. Assuming that nAChRs in human subjects are ready to receive long-lasting messages from the extracellular space because of their predominantly nonsynaptic distribution, they offer an ideal target for drug therapy at low, nontoxic drug levels.

AB - This review attempts to organize the different aspects of nicotinic transmission in the context of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate in the nonsynaptic mode in the central nervous system despite their ligand-gated ion-channel nature, which would otherwise be better suited for fast synaptic transmission. This fast form of nonsynaptic transmission, most likely unique to nAChRs, represents a new avenue in the communication platforms of the brain. Cholinergic messages received by nAChRs, arriving at a later phase following synaptic activation, can interfere with dendritic signal integration. Nicotinic transmission plays a role in both neural plasticity and cellular learning processes, as well as in long-term changes in basic activity through fast activation, desensitization of receptors, and fluctuations of the steady-state levels of ACh. ACh release can contribute to plastic changes via activation of nAChRs in neurons and therefore plays a role in learning and memory in different brain regions. Assuming that nAChRs in human subjects are ready to receive long-lasting messages from the extracellular space because of their predominantly nonsynaptic distribution, they offer an ideal target for drug therapy at low, nontoxic drug levels.

UR - http://www.scopus.com/inward/record.url?scp=42049100322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42049100322&partnerID=8YFLogxK

U2 - 10.1152/physrev.00040.2006

DO - 10.1152/physrev.00040.2006

M3 - Article

VL - 88

SP - 333

EP - 349

JO - Physiological Reviews

JF - Physiological Reviews

SN - 0031-9333

IS - 2

ER -