Abstract
SUMMARYAstroviruses are thought to be enteric pathogens. Since 2010, a certain group of astroviruses has increasingly been recognized, using up-to-date random amplification and high-throughput next-generation sequencing (NGS) methods, as potential neurovirulent (Ni) pathogens of severe central nervous system (CNS) infections, causing encephalitis, meningoencephalitis, and meningoencephalomyelitis. To date, neurovirulent astrovirus cases or epidemics have been reported for humans and domesticated mammals, including mink, bovines, ovines, and swine. This comprehensive review summarizes the virology, epidemiology, pathology, diagnosis, therapy, and future perspective related to neurovirulent astroviruses in humans and mammals, based on a total of 30 relevant articles available in PubMed (searched by use of the terms "astrovirus/encephalitis" and "astrovirus/meningitis" on 2 March 2018). A paradigm shift should be considered based on the increasing knowledge of the causality-effect association between neurotropic astroviruses and CNS infection, and attention should be drawn to the role of astroviruses in unknown CNS diseases.
| Original language | English |
|---|---|
| Journal | Clinical Microbiology Reviews |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
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Keywords
- animal
- astrovirus
- encephalitis
- human
- meningitis
- meningoencephalomyelitis
- neurotropic
- neurovirulent
ASJC Scopus subject areas
- Epidemiology
- Immunology and Microbiology(all)
- Public Health, Environmental and Occupational Health
- Microbiology (medical)
- Infectious Diseases
Cite this
Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals. / Reuter, G.; Pankovics, P.; Boros, Ákos.
In: Clinical Microbiology Reviews, Vol. 31, No. 4, 01.10.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Nonsuppurative (Aseptic) Meningoencephalomyelitis Associated with Neurovirulent Astrovirus Infections in Humans and Animals
AU - Reuter, G.
AU - Pankovics, P.
AU - Boros, Ákos
PY - 2018/10/1
Y1 - 2018/10/1
N2 - SUMMARYAstroviruses are thought to be enteric pathogens. Since 2010, a certain group of astroviruses has increasingly been recognized, using up-to-date random amplification and high-throughput next-generation sequencing (NGS) methods, as potential neurovirulent (Ni) pathogens of severe central nervous system (CNS) infections, causing encephalitis, meningoencephalitis, and meningoencephalomyelitis. To date, neurovirulent astrovirus cases or epidemics have been reported for humans and domesticated mammals, including mink, bovines, ovines, and swine. This comprehensive review summarizes the virology, epidemiology, pathology, diagnosis, therapy, and future perspective related to neurovirulent astroviruses in humans and mammals, based on a total of 30 relevant articles available in PubMed (searched by use of the terms "astrovirus/encephalitis" and "astrovirus/meningitis" on 2 March 2018). A paradigm shift should be considered based on the increasing knowledge of the causality-effect association between neurotropic astroviruses and CNS infection, and attention should be drawn to the role of astroviruses in unknown CNS diseases.
AB - SUMMARYAstroviruses are thought to be enteric pathogens. Since 2010, a certain group of astroviruses has increasingly been recognized, using up-to-date random amplification and high-throughput next-generation sequencing (NGS) methods, as potential neurovirulent (Ni) pathogens of severe central nervous system (CNS) infections, causing encephalitis, meningoencephalitis, and meningoencephalomyelitis. To date, neurovirulent astrovirus cases or epidemics have been reported for humans and domesticated mammals, including mink, bovines, ovines, and swine. This comprehensive review summarizes the virology, epidemiology, pathology, diagnosis, therapy, and future perspective related to neurovirulent astroviruses in humans and mammals, based on a total of 30 relevant articles available in PubMed (searched by use of the terms "astrovirus/encephalitis" and "astrovirus/meningitis" on 2 March 2018). A paradigm shift should be considered based on the increasing knowledge of the causality-effect association between neurotropic astroviruses and CNS infection, and attention should be drawn to the role of astroviruses in unknown CNS diseases.
KW - animal
KW - astrovirus
KW - encephalitis
KW - human
KW - meningitis
KW - meningoencephalomyelitis
KW - neurotropic
KW - neurovirulent
UR - http://www.scopus.com/inward/record.url?scp=85058521327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058521327&partnerID=8YFLogxK
U2 - 10.1128/CMR.00040-18
DO - 10.1128/CMR.00040-18
M3 - Review article
C2 - 30158300
AN - SCOPUS:85058521327
VL - 31
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
SN - 0893-8512
IS - 4
ER -