Nonlinearity in optical resolution via distillation applying mixtures of resolving agents

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

During an optical resolution it is the resolving agent that has the strongest influence on the outcome of the process. Applying a mixture of resolving agents can result either in antagonism or in synergy. We found that using mixtures of tartaric acid and its derivatives chiral selectivity is at least the same, but in several cases markedly better (synergistic effect), than the sum of the effect of the individual resolving agents. Thus, the "Dutch method," reported for the crystallization method, also works for distillation. A calculation method is applied for measuring the synergistic effect. Interestingly, an individually inactive resolving agent can be a useful contributor to the mixture of the resolving agents.

Original languageEnglish
Pages (from-to)674-676
Number of pages3
JournalChirality
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 3 2002

    Fingerprint

Keywords

  • Chiral recognition
  • Dutch resolution
  • Enantiomer separation
  • Mixtures
  • Synergistic effect

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this