Nonlinear relationship between V+max and h infinity in frog skeletal muscle.

P. P. Nánási, M. Dankó, A. Varró, D. A. Lathrop

Research output: Contribution to journalArticle

1 Citation (Scopus)


The relationship between the maximum velocity of action potential upstroke (V+max) and steady-state Na+ channel inactivation (h infinity) was studied in frog skeletal muscle during repetitive discharges evoked in the presence of cevadine (1 mumol/l). Conventional microelectrodes and vaseline-gap voltage-clamp techniques were used. A severe degree of nonlinearity was found between (h infinity) and (V+max) especially when the Na+ conductance (gNa) was small. The observed nonlinearity could be explained as a property of the normal Na+ channel gating in skeletal muscle rather than that of cevadine-modified channels. Part of this work has been published in abstract form in Biophys. J. 57: 105A, 1990.

Original languageEnglish
Pages (from-to)159-167
Number of pages9
JournalGeneral physiology and biophysics
Issue number2
Publication statusPublished - Apr 1992

ASJC Scopus subject areas

  • Biophysics
  • Physiology

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