Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance

Suzsanna Putz, Adám Gtabák, Nelli Toth, Ildiko Istenes, Nora Nemeth, Rajiv A. Gandhi, Zsolt Hermanyi, Katalin Kereszes, G. Jermendy, Solomon Tesaye, P. Kempler

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

OBJECTIVE - To evaluate neural dysfunction in subjects with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS - For this study, 46 subjects with IGT and 45 healthy volunteers underwent detailed neurological assessment. Cardiovascular autonomic function was assessed by standard cardiovascular reflex tests, and heart rate variability was characterized by the triangle index. Sensory nerve function was assessed using Neurometer (for current perception threshold) and Medoc devices. Peak plantar pressure was measured by dynamic pedobarography, and symptoms were graded using the neuropathy total symptom score. RESULTS - Subjects with IGT had significantly greater abnormalities detected by four of five cardiovascular reflex tests and greater heart rate variability characterized by the triangle index. They had a higher frequency of both hyperesthesia and hypoesthesia as detected by current perception threshold testing at 5 Hz, as well as increased heat detection thresholds. CONCLUSIONS - This study provides evidence that subclinical neural dysfunction is present in subjects with IGT and can be detected noninvasively. Cardiovascular autonomic neuropathy may contribute to increased cardiovascular risk in IGT subjects.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalDiabetes Care
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Glucose Intolerance
Reflex
Heart Rate
Hyperesthesia
Hypesthesia
Healthy Volunteers
Research Design
Hot Temperature
Pressure
Equipment and Supplies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Putz, S., Gtabák, A., Toth, N., Istenes, I., Nemeth, N., Gandhi, R. A., ... Kempler, P. (2009). Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance. Diabetes Care, 32(1), 181-183. https://doi.org/10.2337/dc08-1406

Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance. / Putz, Suzsanna; Gtabák, Adám; Toth, Nelli; Istenes, Ildiko; Nemeth, Nora; Gandhi, Rajiv A.; Hermanyi, Zsolt; Kereszes, Katalin; Jermendy, G.; Tesaye, Solomon; Kempler, P.

In: Diabetes Care, Vol. 32, No. 1, 01.2009, p. 181-183.

Research output: Contribution to journalArticle

Putz, S, Gtabák, A, Toth, N, Istenes, I, Nemeth, N, Gandhi, RA, Hermanyi, Z, Kereszes, K, Jermendy, G, Tesaye, S & Kempler, P 2009, 'Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance', Diabetes Care, vol. 32, no. 1, pp. 181-183. https://doi.org/10.2337/dc08-1406
Putz S, Gtabák A, Toth N, Istenes I, Nemeth N, Gandhi RA et al. Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance. Diabetes Care. 2009 Jan;32(1):181-183. https://doi.org/10.2337/dc08-1406
Putz, Suzsanna ; Gtabák, Adám ; Toth, Nelli ; Istenes, Ildiko ; Nemeth, Nora ; Gandhi, Rajiv A. ; Hermanyi, Zsolt ; Kereszes, Katalin ; Jermendy, G. ; Tesaye, Solomon ; Kempler, P. / Noninvasive evaluation of neural impairment in subjects with impaired glucose tolerance. In: Diabetes Care. 2009 ; Vol. 32, No. 1. pp. 181-183.
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