Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel

Translated title of the contribution: Noninvasive assessment of endothelial function in hemodialized hypertensive patients by laser Doppler flowmetry

Katalin Farkas, János Nemcsik, Endre Kolossváry, Z. Járai, János Borvendég, Éva Nádory, C. Farsang, István Kiss

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: End stage renal disease and hypertension are associated with higher cardiovascular mortality. Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. The authors investigated the endothel-dependent and -independent vasodilation in the forearm skin microcirculation and the plasma markers of endothelial damage in hypertensive hemodialysed patients and in normotensive control subjects. Methods: Laser Doppler flowmetry with iontophoresis of acetylcholine and sodium nitroprusside and the postocclusive reactive hyperemia test was performed in 22 normal control subjects and in 21 hemodialysed patients with hypertension. Levels of endothelin-1, big-endothelin, and von Willebrand Factor were measured, as well. Results: The average hyperemic response to the two doses of acetylcholine iontophoresis was 474 ± 83%; 836 ± 97% in the control subjects, and 160 ± 26%; 360 ± 67% in the hemodialysed patients group (p <0.05). The vasodilation after the two doses of sodium nitroprusside was 381 ± 60%, 782 ± 81% in the control group and 186 ± 42%; 379 ± 63% in the dialysed patients group (p <0.05 compared to control, respectively). The average peak flow during the postocclusive reactive hyperemia test was significantly lower in hemodialysed hypertensives (234 ± 48%) compared to healthy control subjects (434 ± 36%, p <0.05). Levels of endothelin-1, big endothelin, von Willebrand Factor and von Willebrand Factor activity were significantly higher in the patient group compared to the control subjects. Conclusions: In hemodialysed hypertensive patients, both endothel-dependent and independent vasodilation are impaired. Markers of endothelial damage are elevated referring the progression of vascular disease.

Original languageHungarian
Pages (from-to)2589-2594
Number of pages6
JournalOrvosi Hetilap
Volume146
Issue number51
Publication statusPublished - 2005

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Laser-Doppler Flowmetry
Endothelin-1
von Willebrand Factor
Vasodilation
Iontophoresis
Hyperemia
Nitroprusside
Acetylcholine
Renal Hypertension
Microcirculation
Vascular Diseases
Forearm
Chronic Kidney Failure
Healthy Volunteers
Cardiovascular Diseases
Hypertension
Control Groups
Skin
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Farkas, K., Nemcsik, J., Kolossváry, E., Járai, Z., Borvendég, J., Nádory, É., ... Kiss, I. (2005). Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel. Orvosi Hetilap, 146(51), 2589-2594.

Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel. / Farkas, Katalin; Nemcsik, János; Kolossváry, Endre; Járai, Z.; Borvendég, János; Nádory, Éva; Farsang, C.; Kiss, István.

In: Orvosi Hetilap, Vol. 146, No. 51, 2005, p. 2589-2594.

Research output: Contribution to journalArticle

Farkas, K, Nemcsik, J, Kolossváry, E, Járai, Z, Borvendég, J, Nádory, É, Farsang, C & Kiss, I 2005, 'Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel', Orvosi Hetilap, vol. 146, no. 51, pp. 2589-2594.
Farkas K, Nemcsik J, Kolossváry E, Járai Z, Borvendég J, Nádory É et al. Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel. Orvosi Hetilap. 2005;146(51):2589-2594.
Farkas, Katalin ; Nemcsik, János ; Kolossváry, Endre ; Járai, Z. ; Borvendég, János ; Nádory, Éva ; Farsang, C. ; Kiss, István. / Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel. In: Orvosi Hetilap. 2005 ; Vol. 146, No. 51. pp. 2589-2594.
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abstract = "Background: End stage renal disease and hypertension are associated with higher cardiovascular mortality. Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. The authors investigated the endothel-dependent and -independent vasodilation in the forearm skin microcirculation and the plasma markers of endothelial damage in hypertensive hemodialysed patients and in normotensive control subjects. Methods: Laser Doppler flowmetry with iontophoresis of acetylcholine and sodium nitroprusside and the postocclusive reactive hyperemia test was performed in 22 normal control subjects and in 21 hemodialysed patients with hypertension. Levels of endothelin-1, big-endothelin, and von Willebrand Factor were measured, as well. Results: The average hyperemic response to the two doses of acetylcholine iontophoresis was 474 ± 83{\%}; 836 ± 97{\%} in the control subjects, and 160 ± 26{\%}; 360 ± 67{\%} in the hemodialysed patients group (p <0.05). The vasodilation after the two doses of sodium nitroprusside was 381 ± 60{\%}, 782 ± 81{\%} in the control group and 186 ± 42{\%}; 379 ± 63{\%} in the dialysed patients group (p <0.05 compared to control, respectively). The average peak flow during the postocclusive reactive hyperemia test was significantly lower in hemodialysed hypertensives (234 ± 48{\%}) compared to healthy control subjects (434 ± 36{\%}, p <0.05). Levels of endothelin-1, big endothelin, von Willebrand Factor and von Willebrand Factor activity were significantly higher in the patient group compared to the control subjects. Conclusions: In hemodialysed hypertensive patients, both endothel-dependent and independent vasodilation are impaired. Markers of endothelial damage are elevated referring the progression of vascular disease.",
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T1 - Az endothelfunkció noninvazív vizsgálata dializált hypertoniás betegekben lézer Doppler- áramlásméréssel

AU - Farkas, Katalin

AU - Nemcsik, János

AU - Kolossváry, Endre

AU - Járai, Z.

AU - Borvendég, János

AU - Nádory, Éva

AU - Farsang, C.

AU - Kiss, István

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N2 - Background: End stage renal disease and hypertension are associated with higher cardiovascular mortality. Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. The authors investigated the endothel-dependent and -independent vasodilation in the forearm skin microcirculation and the plasma markers of endothelial damage in hypertensive hemodialysed patients and in normotensive control subjects. Methods: Laser Doppler flowmetry with iontophoresis of acetylcholine and sodium nitroprusside and the postocclusive reactive hyperemia test was performed in 22 normal control subjects and in 21 hemodialysed patients with hypertension. Levels of endothelin-1, big-endothelin, and von Willebrand Factor were measured, as well. Results: The average hyperemic response to the two doses of acetylcholine iontophoresis was 474 ± 83%; 836 ± 97% in the control subjects, and 160 ± 26%; 360 ± 67% in the hemodialysed patients group (p <0.05). The vasodilation after the two doses of sodium nitroprusside was 381 ± 60%, 782 ± 81% in the control group and 186 ± 42%; 379 ± 63% in the dialysed patients group (p <0.05 compared to control, respectively). The average peak flow during the postocclusive reactive hyperemia test was significantly lower in hemodialysed hypertensives (234 ± 48%) compared to healthy control subjects (434 ± 36%, p <0.05). Levels of endothelin-1, big endothelin, von Willebrand Factor and von Willebrand Factor activity were significantly higher in the patient group compared to the control subjects. Conclusions: In hemodialysed hypertensive patients, both endothel-dependent and independent vasodilation are impaired. Markers of endothelial damage are elevated referring the progression of vascular disease.

AB - Background: End stage renal disease and hypertension are associated with higher cardiovascular mortality. Endothelial dysfunction plays an important role in the pathogenesis of cardiovascular diseases. The authors investigated the endothel-dependent and -independent vasodilation in the forearm skin microcirculation and the plasma markers of endothelial damage in hypertensive hemodialysed patients and in normotensive control subjects. Methods: Laser Doppler flowmetry with iontophoresis of acetylcholine and sodium nitroprusside and the postocclusive reactive hyperemia test was performed in 22 normal control subjects and in 21 hemodialysed patients with hypertension. Levels of endothelin-1, big-endothelin, and von Willebrand Factor were measured, as well. Results: The average hyperemic response to the two doses of acetylcholine iontophoresis was 474 ± 83%; 836 ± 97% in the control subjects, and 160 ± 26%; 360 ± 67% in the hemodialysed patients group (p <0.05). The vasodilation after the two doses of sodium nitroprusside was 381 ± 60%, 782 ± 81% in the control group and 186 ± 42%; 379 ± 63% in the dialysed patients group (p <0.05 compared to control, respectively). The average peak flow during the postocclusive reactive hyperemia test was significantly lower in hemodialysed hypertensives (234 ± 48%) compared to healthy control subjects (434 ± 36%, p <0.05). Levels of endothelin-1, big endothelin, von Willebrand Factor and von Willebrand Factor activity were significantly higher in the patient group compared to the control subjects. Conclusions: In hemodialysed hypertensive patients, both endothel-dependent and independent vasodilation are impaired. Markers of endothelial damage are elevated referring the progression of vascular disease.

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KW - Chronic renal failure

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KW - Von Willebrand factor

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