Nonadherence in inflammatory bowel disease

Results of factor analysis

Petr Červený, Martin Bortlík, Aleš Kuběna, Jiří Vlček, P. Lakatos, Milan Lukáš

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Background: The purpose of the study was to assess overall nonadherence to treatment among patients with Crohn's disease (CD) and ulcerative colitis (UC) in a single tertiary center. Methods: A total of 177 patients were enrolled in this study (84 males, 93 females; 117 CD, 60 UC). Patients were interviewed about their nonadherent behavior and their answers were analyzed using factor analysis. Urine samples were collected from a subcohort of 47 patients treated by mesalamine to verify the presence of 5-ASA or its metabolites. Results: Overall intentional nonadherence was reported by 38.9% of patients; 18.6% of the patients discontinued the treatment at least once. Intentional dose reduction was reported by 18% of patients; 14.7% of patients occasionally did not refill their medications on time. There were no differences in adherence between males and females, disease type, previous bowel surgery, or marital, smoking, and nonsmoking status. More than 38% of patients reported unintentional nonadherence. Factor analysis proved that nonadherence increased with a higher education level of the patients and decreased with older age. Adverse drug effects strongly contributed to nonadherence. Nonadherent patients were more likely to be chronically active or in relapse (τ = 0.212; P = 0.002). In the group of 47 patients whose urine was analyzed, 6 cases (12.7%) were negative for mesalamine or its metabolite. Conclusions: The overall intentional nonadherence with medical therapy is relatively high among IBD patients and should be taken into account when a patient's response to treatment is unsatisfactory. Therefore, problems of nonadherence should be discussed with all IBD patients.

Original languageEnglish
Pages (from-to)1244-1249
Number of pages6
JournalInflammatory Bowel Diseases
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Inflammatory Bowel Diseases
Statistical Factor Analysis
Mesalamine
Ulcerative Colitis
Crohn Disease
Urine
Patient Education
Therapeutics
Smoking

Keywords

  • Crohn's disease
  • Mesalamine
  • Patient compliance
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Červený, P., Bortlík, M., Kuběna, A., Vlček, J., Lakatos, P., & Lukáš, M. (2007). Nonadherence in inflammatory bowel disease: Results of factor analysis. Inflammatory Bowel Diseases, 13(10), 1244-1249. https://doi.org/10.1002/ibd.20189

Nonadherence in inflammatory bowel disease : Results of factor analysis. / Červený, Petr; Bortlík, Martin; Kuběna, Aleš; Vlček, Jiří; Lakatos, P.; Lukáš, Milan.

In: Inflammatory Bowel Diseases, Vol. 13, No. 10, 10.2007, p. 1244-1249.

Research output: Contribution to journalArticle

Červený, P, Bortlík, M, Kuběna, A, Vlček, J, Lakatos, P & Lukáš, M 2007, 'Nonadherence in inflammatory bowel disease: Results of factor analysis', Inflammatory Bowel Diseases, vol. 13, no. 10, pp. 1244-1249. https://doi.org/10.1002/ibd.20189
Červený, Petr ; Bortlík, Martin ; Kuběna, Aleš ; Vlček, Jiří ; Lakatos, P. ; Lukáš, Milan. / Nonadherence in inflammatory bowel disease : Results of factor analysis. In: Inflammatory Bowel Diseases. 2007 ; Vol. 13, No. 10. pp. 1244-1249.
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