Non-syndromic malformations of the central nervous system in twin pregnancies: Diagnostic and other clinical features of importance

József Gábor Joó, Éva Csatlós, Balázs Börzsönyi, Csaba Demendi, Ákos Csaba, János Rigó

Research output: Contribution to journalArticle

2 Citations (Scopus)


Objective: The incidence of central nervous system malformations is higher among twins. Our aim was to summarize information about these malformations in twin pregnancies. Study design: Based on a sample originating from the biggest genetic centre in Hungary between January 1990 and December 2008, we examined the data of 42 twin pregnancies associated with non-syndromic malformations of the central nervous system. Results: The involvement of monozygotic fetuses and dizygotic ones of the same gender was found to be 62.5%. Usually only one of the fetuses was affected (57.1%), while the other one was healthy. The male-to-female ratio was 0.75. Identical and fraternal twins were found in 68.4% and 31.6% of the cases, respectively. In the pregnancies of our study the malformation was diagnosed before the 24th gestational week in 90% of the cases. Polyhydramnios (54.8%) was the most commonly associated non-central nervous system malformation. Conclusion: Our findings suggest that, in addition to placentation and gestational age, the position of the affected fetus with relation to the uterine orifice is of great importance in determining whether selective abortion is an option in deciding about the outcome of pregnancies affected by craniospinal malformation.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - Jan 2011


  • Genetic counselling
  • Induced abortion
  • Malformation of the central nervous system
  • Selective termination of pregnancy
  • Twin pregnancy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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