Non-opioid actions of opioid peptides

Mária Wollemann, S. Benyhe

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Beside the well known actions of opioid peptides on μ-, δ- and κ-opioid receptors, increasing amount of pharmacological and biochemical evidence has recently been published about non-opioid actions of various opioid peptides. These effects are not abolished by naloxone treatments. Such non-opioid effects are observed both in nervous tissues and in the cellular elements of the immune system. Peptides exhibiting non-opioid effects include β-endorphin, dynorphin A, nociceptin/OFQ, endomorphins, hemorphins and a number of Proenkephalin A derived peptides, such as Met-enkephalin, Met-enkephalin-Arg-Phe (MERF) and bovine adrenal medullary peptide (BAM22). Non-opioid actions are exerted through different neuronal receptors, e.g., dynorphin hyperalgesia through NMDA receptor, Met-enkephalin induced regulation of cell growth through zeta (ζ) receptors, pain modulation by nociceptin through ORL-1 or NOP receptors, while BAM22 acts through sensory neuron specific G protein-coupled receptors (SNSR). We have investigated Met-enkephalin-Arg-Phe (MERF) and its analogues by the means of direct and indirect radioligand binding assays. It has been found that in addition to κ2 and δ-opioid receptors, MERF can act also through σ2- or probably via FMRF-NH2 receptors in rat cerebellum. A role of functionally assembling heterodimer receptors in mediating the non-conventional actions of these peptide ligands can not be excluded as well.

Original languageEnglish
Pages (from-to)257-270
Number of pages14
JournalLife Sciences
Volume75
Issue number3
DOIs
Publication statusPublished - Jun 4 2004

Fingerprint

Methionine Enkephalin
Opioid Peptides
Dynorphins
Opioid Receptors
Peptides
FMRFamide
Endorphins
Nerve Tissue
Radioligand Assay
Immune system
Hyperalgesia
Cell growth
Sensory Receptor Cells
Naloxone
G-Protein-Coupled Receptors
N-Methyl-D-Aspartate Receptors
Cerebellum
Neurons
Rats
Immune System

Keywords

  • Naloxone
  • Non-opioid mechanisms
  • Opioid peptides
  • Receptors

ASJC Scopus subject areas

  • Pharmacology

Cite this

Non-opioid actions of opioid peptides. / Wollemann, Mária; Benyhe, S.

In: Life Sciences, Vol. 75, No. 3, 04.06.2004, p. 257-270.

Research output: Contribution to journalArticle

Wollemann, Mária ; Benyhe, S. / Non-opioid actions of opioid peptides. In: Life Sciences. 2004 ; Vol. 75, No. 3. pp. 257-270.
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