Nem nutritív bioaktív növényi komponensek

A glükozinolátok étrendi forrásai és táplálkozás-élettani jelentoségük

Translated title of the contribution: Non-nutritive biologically active plant components: Glucosinolates, their sources and nutritional importance

A. Lugasi, Tünde Varga

Research output: Contribution to journalArticle

Abstract

Numerous epidemiological studies as well as experimental animal studies suggest that a high intake of cruciferous vegetables is associated with a reduced risk of various forms of cancer. This protective effect has been linked to the high glucosinolate content of these vegetables. Glucosinolate breakdown products, particularly isothiocyanates and nitriles have been shown to modulate carcinogen metabolising enzyme systems, induce cell cycle arrest or apoptosis. The anticancer potential of the different glucosinolate metabolites is diverse and their effect on the above mentioned cellular mechanisms is also affected by the model system employed. Results of in vivo studies with isolated glucosinolates or isothiocyanates compared to those with cruciferous vegetables demonstrate that the chemopreventive effect of cruciferous vegetables is due to combined effect of the different glucosinolate metabolites and the optimal combination of these compounds found in Cruciferae provide the beneficial health effects.

Original languageHungarian
Pages (from-to)1361-1368
Number of pages8
JournalOrvosi Hetilap
Volume147
Issue number29
Publication statusPublished - Jul 23 2006

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Glucosinolates
Plant Structures
Vegetables
Isothiocyanates
Brassicaceae
Nitriles
Cell Cycle Checkpoints
Carcinogens
Epidemiologic Studies
Apoptosis
Health
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nem nutritív bioaktív növényi komponensek : A glükozinolátok étrendi forrásai és táplálkozás-élettani jelentoségük. / Lugasi, A.; Varga, Tünde.

In: Orvosi Hetilap, Vol. 147, No. 29, 23.07.2006, p. 1361-1368.

Research output: Contribution to journalArticle

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