Non-NMDA receptor-mediated modulation of voltage-activated outward currents in chick neurones

Arpad Mike, Vladimir A. Dyatlov, E. Sylvester Vizi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of kainate on the voltage-activated current of cultured embryonic chick telencephalic neurones was studied by whole-cell voltage clamp recording. In addition to opening non-NMDA receptor coupled ion channels, kainate produced additional effects, with a slower time course: it modulated voltage-activated currents. These effects were blocked by the non-NMDA receptor antagonists CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) and GYKI 53784 ((-)-1-(4-aminophenyl)-3-methylcarbamoyl-4-methyl-7,8-methylenedioxy-3,4 -dihydro-5H-2,3-benzodiazepine), indicating that non NMDA receptors are involved. It has been shown that the reversible inhibition of outward potassium currents was partly due to a decrease of current amplitude and partly to a marked shift of the inactivation curve towards more negative potentials.

Original languageEnglish
Pages (from-to)2613-2617
Number of pages5
JournalNeuroreport
Volume7
Issue number15-17
Publication statusPublished - Dec 14 1996

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Keywords

  • Chick
  • Glutamate receptors
  • Kainate
  • Telencephalic neurones
  • Voltage-gated ion channels

ASJC Scopus subject areas

  • Neuroscience(all)

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