Non-NMDA receptor antagonist GYKI 52466 suppresses cortical after discharges in immature rats

Hana Kubová, I. Világi, Anna Mikulecká, Pavel Mareš

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

GYKI 52466 (1-(4-aminophenyl)-3-methyl-7,8-methylendioxy-5H-2,3-benzo-diazepine), a non-competitive non-NMDA receptor antagonist, was tested against epileptic afterdischarges elicited by cortical stimulation in 12-, 18- and 25-day-old rats with implanted electrodes. Shortening of afterdischarges and a decrease in intensity of clonic movements accompanying both stimulation and afterdischarges were induced by the 20 mg/kg dose of GYKI 52466 in 18- and 25-day-old animals, whereas 12-day-old rat pups exhibited only shortening of electroencephalographic afterdischarges. The 10 mg/kg dose of GYKI 52466 did not significantly change afterdischarges in any age group. Motor skills were compromised after the 20 mg/kg dose of GYKI 52466. This effect was again more marked in 18- and 25-day-old animals than in the youngest group. In addition, anxiolytic-like action was observed in the jumping down test in 25-day-old rats. This effect was not influenced by a benzodiazepine antagonist flumazenil. On the contrary, the anticonvulsant action of GYKI 52466 was partly blocked by flumazenil, indicating thus multiple mechanisms of action of GYKI 52466.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalEuropean Journal of Pharmacology
Volume333
Issue number1
DOIs
Publication statusPublished - Aug 20 1997

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Flumazenil
Implanted Electrodes
Motor Skills
Anti-Anxiety Agents
Benzodiazepines
Anticonvulsants
GYKI 52466
Age Groups

Keywords

  • Anticonvulsant action
  • Excitatory amino acid
  • Flumazenil
  • GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8 methylendioxy- 5H-2,3-benzo-diazepine)
  • Motor system

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Non-NMDA receptor antagonist GYKI 52466 suppresses cortical after discharges in immature rats. / Kubová, Hana; Világi, I.; Mikulecká, Anna; Mareš, Pavel.

In: European Journal of Pharmacology, Vol. 333, No. 1, 20.08.1997, p. 17-26.

Research output: Contribution to journalArticle

Kubová, Hana ; Világi, I. ; Mikulecká, Anna ; Mareš, Pavel. / Non-NMDA receptor antagonist GYKI 52466 suppresses cortical after discharges in immature rats. In: European Journal of Pharmacology. 1997 ; Vol. 333, No. 1. pp. 17-26.
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