Non-linear relationship of cell hit and transformation probabilities in a low dose of inhaled radon progenies

Imre Balásházy, Árpád Farkas, Balázs Gergely Madas, Werner Hofmann

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cellular hit probabilities of alpha particles emitted by inhaled radon progenies in sensitive bronchial epithelial cell nuclei were simulated at low exposure levels to obtain useful data for the rejection or support of the linear-non-threshold (LNT) hypothesis. In this study, local distributions of deposited inhaled radon progenies in airway bifurcation models were computed at exposure conditions characteristic of homes and uranium mines. Then, maximum local deposition enhancement factors at bronchial airway bifurcations, expressed as the ratio of local to average deposition densities, were determined to characterise the inhomogeneity of deposition and to elucidate their effect on resulting hit probabilities. The results obtained suggest that in the vicinity of the carinal regions of the central airways the probability of multiple hits can be quite high, even at low average doses. Assuming a uniform distribution of activity there are practically no multiple hits and the hit probability as a function of dose exhibits a linear shape in the low dose range. The results are quite the opposite in the case of hot spots revealed by realistic deposition calculations, where practically all cells receive multiple hits and the hit probability as a function of dose is non-linear in the average dose range of 10-100mGy.

Original languageEnglish
Pages (from-to)147-162
Number of pages16
JournalJournal of Radiological Protection
Volume29
Issue number2
DOIs
Publication statusPublished - Nov 16 2009

ASJC Scopus subject areas

  • Waste Management and Disposal
  • Public Health, Environmental and Occupational Health

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