Non-invasive assessment of microvascular endothelial function by laser doppler flowmetry in patients with essential hypertension

Katalin Farkas, Endre Kolossváry, Z. Járai, János Nemcsik, C. Farsang

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The aim of the study was to investigate the endothelium-dependent vasodilation in the forearm skin using two non-invasive laser Doppler applications in patients with essential hypertension (EHT) and in normotensive (NT) control subjects. The effect of two consecutive doses of acetylcholine (ACh) and that of sodium nitroprusside (SNP) on the skin microcirculation, and thereafter the postocclusive reactive hyperaemic (PORH) response, were measured in 25 patients with essential hypertension and also in 25 control normotensive healthy subjects. The plasma von Willebrand factor (vWF) level and activity were also determined. The average peakflow in PORH was 287±31.5% (x±S.E.M.) in EHT and 410.28±35.08% in NT (P

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalAtherosclerosis
Volume173
Issue number1
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Laser-Doppler Flowmetry
Skin
von Willebrand Factor
Nitroprusside
Microcirculation
Forearm
Vasodilation
Acetylcholine
Endothelium
Healthy Volunteers
Lasers
Essential Hypertension

Keywords

  • Acetylcholine
  • Endothelium
  • Essential hypertension
  • Laser Doppler flowmetry
  • Skin microcirculation
  • von Willebrand factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Non-invasive assessment of microvascular endothelial function by laser doppler flowmetry in patients with essential hypertension. / Farkas, Katalin; Kolossváry, Endre; Járai, Z.; Nemcsik, János; Farsang, C.

In: Atherosclerosis, Vol. 173, No. 1, 03.2004, p. 97-102.

Research output: Contribution to journalArticle

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