Non-fibrous zeolite induced experimental pneumoconiosis in rats

E. Tátrai, I. Wojnarovits, G. Ungvary

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A study was made on the pulmonary pathological reactions after intratracheal introduction of non-fibrous zeolite into CFY rats in long-term sequential investigations (1st week; 1st, 3rd, 6th months and 1st year). After treatment at the end of the 1st week non-specific confluating bronchopneumonia followed by a storage type reaction developed at the end of the 1st month. In the later periods in addition to storage charakter mild pulmonary fibrosis has been observed. At the end of the 1st year, transmission electron microscopy and X-ray microanalysis verified that aluminium and silicon ratio in zeolite storaged in the macrophages of the lungs was the same as found in natural zeolite (1: 6). In the lungs of 3 animals atypical hyperplasia developed; therefore an in vivo study of the carcinogenic effect of non-fibrous zeolite seemed justified.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalExperimental Pathology
Volume43
Issue number1-2
Publication statusPublished - 1991

Fingerprint

Zeolites
Pneumoconiosis
Rats
Lung
Electron Probe Microanalysis
Bronchopneumonia
Pulmonary Fibrosis
Macrophages
Silicon
Aluminum
Transmission Electron Microscopy
Hyperplasia
Animals
Transmission electron microscopy
X rays

Keywords

  • Lung
  • Pneumoconiosis
  • Pulmonary fibrosis
  • Storage-type reaction
  • Zeolite

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Non-fibrous zeolite induced experimental pneumoconiosis in rats. / Tátrai, E.; Wojnarovits, I.; Ungvary, G.

In: Experimental Pathology, Vol. 43, No. 1-2, 1991, p. 41-46.

Research output: Contribution to journalArticle

Tátrai, E, Wojnarovits, I & Ungvary, G 1991, 'Non-fibrous zeolite induced experimental pneumoconiosis in rats', Experimental Pathology, vol. 43, no. 1-2, pp. 41-46.
Tátrai, E. ; Wojnarovits, I. ; Ungvary, G. / Non-fibrous zeolite induced experimental pneumoconiosis in rats. In: Experimental Pathology. 1991 ; Vol. 43, No. 1-2. pp. 41-46.
@article{65404f62980947c1b1da0352d81c3004,
title = "Non-fibrous zeolite induced experimental pneumoconiosis in rats",
abstract = "A study was made on the pulmonary pathological reactions after intratracheal introduction of non-fibrous zeolite into CFY rats in long-term sequential investigations (1st week; 1st, 3rd, 6th months and 1st year). After treatment at the end of the 1st week non-specific confluating bronchopneumonia followed by a storage type reaction developed at the end of the 1st month. In the later periods in addition to storage charakter mild pulmonary fibrosis has been observed. At the end of the 1st year, transmission electron microscopy and X-ray microanalysis verified that aluminium and silicon ratio in zeolite storaged in the macrophages of the lungs was the same as found in natural zeolite (1: 6). In the lungs of 3 animals atypical hyperplasia developed; therefore an in vivo study of the carcinogenic effect of non-fibrous zeolite seemed justified.",
keywords = "Lung, Pneumoconiosis, Pulmonary fibrosis, Storage-type reaction, Zeolite",
author = "E. T{\'a}trai and I. Wojnarovits and G. Ungvary",
year = "1991",
language = "English",
volume = "43",
pages = "41--46",
journal = "Experimental and Toxicologic Pathology",
issn = "0940-2993",
publisher = "Urban und Fischer Verlag Jena",
number = "1-2",

}

TY - JOUR

T1 - Non-fibrous zeolite induced experimental pneumoconiosis in rats

AU - Tátrai, E.

AU - Wojnarovits, I.

AU - Ungvary, G.

PY - 1991

Y1 - 1991

N2 - A study was made on the pulmonary pathological reactions after intratracheal introduction of non-fibrous zeolite into CFY rats in long-term sequential investigations (1st week; 1st, 3rd, 6th months and 1st year). After treatment at the end of the 1st week non-specific confluating bronchopneumonia followed by a storage type reaction developed at the end of the 1st month. In the later periods in addition to storage charakter mild pulmonary fibrosis has been observed. At the end of the 1st year, transmission electron microscopy and X-ray microanalysis verified that aluminium and silicon ratio in zeolite storaged in the macrophages of the lungs was the same as found in natural zeolite (1: 6). In the lungs of 3 animals atypical hyperplasia developed; therefore an in vivo study of the carcinogenic effect of non-fibrous zeolite seemed justified.

AB - A study was made on the pulmonary pathological reactions after intratracheal introduction of non-fibrous zeolite into CFY rats in long-term sequential investigations (1st week; 1st, 3rd, 6th months and 1st year). After treatment at the end of the 1st week non-specific confluating bronchopneumonia followed by a storage type reaction developed at the end of the 1st month. In the later periods in addition to storage charakter mild pulmonary fibrosis has been observed. At the end of the 1st year, transmission electron microscopy and X-ray microanalysis verified that aluminium and silicon ratio in zeolite storaged in the macrophages of the lungs was the same as found in natural zeolite (1: 6). In the lungs of 3 animals atypical hyperplasia developed; therefore an in vivo study of the carcinogenic effect of non-fibrous zeolite seemed justified.

KW - Lung

KW - Pneumoconiosis

KW - Pulmonary fibrosis

KW - Storage-type reaction

KW - Zeolite

UR - http://www.scopus.com/inward/record.url?scp=0026342574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026342574&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 41

EP - 46

JO - Experimental and Toxicologic Pathology

JF - Experimental and Toxicologic Pathology

SN - 0940-2993

IS - 1-2

ER -