Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type

Simona Gurzu, Zoltan Szentirmay, Tivadar Bara, Mihai Turcu, Erika Toth, Tivadar Bara, Ioan Jung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 60-year-old male was admitted to our hospital for gastric cancer. Considering his general condition, total gastrectomy and dissection of regional lymph nodes were performed. Macroscopically, a 45. mm. ×. 20. mm. ×. 10. mm-sized, ulcero-infiltrative tumor located in the esophagogastric junction was described. Microscopically, the tumor consisted of a poorly differentiated adenocarcinoma intermingled with dense lymphoid infiltration predominantly composed of T-cell lymphocytes. The tumor cells infiltrated the submucosa, muscularis and subserosal layers of the stomach, respectively the esophageal adventitia. No metastases were noticed in the 58 regional lymph nodes. Based on the histopathological features, the diagnosis was lymphoepithelioma-like carcinoma, pT3N0 stage. In situ hybridization for Epstein-Barr virus showed no nuclear signal in tumor cells. The p53 expression was observed in fewer than 10% of the tumor cells. Real-time PCR analysis showed microsatellite instability without K-ras mutation in codon 12. No recurrences or metastases were reported 6 months after surgical intervention. No adjuvant therapy was performed.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalPathology Research and Practice
Volume209
Issue number2
DOIs
Publication statusPublished - Feb 15 2013

Keywords

  • Esophagogastric junction
  • K-ras
  • Lymphoepithelioma-like carcinoma
  • Microsatellite instability

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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