Non-covalent associations of cyclomaltooligosaccharides (cyclodextrins) with carotenoids in water. A study on the α- and β-cyclodextrin/ψ,ψ-carotene (lycopene) systems by light scattering, ionspray ionization and tandem mass spectrometry

Andrea Mele, Raniero Mendichi, Antonio Selva, Peter Molnar, Gyula Toth

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Water-soluble complexes of the dietary carotenoid ψ,ψ-carotene (lycopene 1) with cyclomaltohexaose (α-cyclodextrin, αCD) and cyclomaltoheptaose (β-cyclodextrin, βCD) have been prepared and characterized via multiangle light scattering (MALS), ionspray/electrospray ionization (IS/ESI) mass spectrometry (MS) and tandem MS. MALS experiments point out that large aggregates of particles, on the nanometer-size scale, are present in water, with meaningful differences in the shape of the αCD/1 aggregates with respect to βCD/1 analogues. The true 1:1 αCD/1 inclusion complex has been observed by IS/ESIMS and confirmed by tandem MS. The structure of CD/1 aggregations in water is proposed which are consistent with the combined MALS and MS experimental results.

Original languageEnglish
Pages (from-to)1129-1136
Number of pages8
JournalCarbohydrate Research
Volume337
Issue number12
DOIs
Publication statusPublished - Jun 12 2002

Keywords

  • Cyclodextrins
  • Dietary carotenoids
  • Electrospray ionization/ionspray mass spectrometry
  • Inclusion complexes
  • Light scattering
  • Lycopene
  • Nanoparticles
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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