Non-conventional agents for optical resolutions

E. Fogassy, Dávid Kozma

Research output: Contribution to journalArticle

Abstract

In this paper we demonstrate the use of chiral drugs and intermediates as resolving agents on 13 examples from our practice. In 11 cases of 13, the configuration of the enantiomers in the precipitated salt is opposite, which support the assumption that the formation of a "quasi racemate" type diastereoisomeric salt may be preffered, when the racemate and the resolving agent are structurally similar or at least there is no significant difference between their molecular weight.

Original languageEnglish
Pages (from-to)37-45
Number of pages9
JournalMolecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals
Volume276-277
Publication statusPublished - 1996

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Salts
salts
Enantiomers
enantiomers
molecular weight
drugs
Molecular weight
configurations
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

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AB - In this paper we demonstrate the use of chiral drugs and intermediates as resolving agents on 13 examples from our practice. In 11 cases of 13, the configuration of the enantiomers in the precipitated salt is opposite, which support the assumption that the formation of a "quasi racemate" type diastereoisomeric salt may be preffered, when the racemate and the resolving agent are structurally similar or at least there is no significant difference between their molecular weight.

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