Non-collagen proteins of stapedial bone matrix in perilymph of otosclerotic patients

J. Gróf, I. Sziklai, O. Ribári, J. Menyhárt

Research output: Contribution to journalArticle

Abstract

Non-collagen proteins extracted from the otosclerotic stapes footplate, superstructure and temporal cortical bone were compared with the protein patterns of normal and otosclerotic perilymph by analytical isotachophoresis (ITP). Normal and otosclerotic perilymph yielded basically identical isotachophoretic subfractions. Thirteen subfractions were detected moving as anions at pH 9.6 in the normal perilymph, versus 16 subfractions of similar character in the otosclerotic perilymph. Of these 16 protein subfractions, one (which was not detected in the normal perilymph) could be found in the ITP-gram of the stapes footplate non-collagen proteins, but not of the stapes superstructure or temporal cortical bone. Our results support the cencept that protein can enter the inner ear fluid spaces from the otosclerotic bone. The biological significance of these proteins has not yet been clarified.

Original languageEnglish
Pages (from-to)557-563
Number of pages7
JournalActa Oto-Laryngologica
Volume99
Issue number5-6
DOIs
Publication statusPublished - Jan 1 1985

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Non-collagen proteins of stapedial bone matrix in perilymph of otosclerotic patients'. Together they form a unique fingerprint.

  • Cite this