Nem kódoló genom és mikroRNS-ek

Új fejezet a genetika történetében

Translated title of the contribution: Non-coding genome and micro-RNAs: A new chapter in the history of genetics

Molnár Viktor, Bakos Beáta, H. Hegyesi, A. Falus

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Since the discovery of the function of the deoxyribonucleic acid, research for decades focused on studying the protein coding regions in ever increasing details. At the same time, non-coding DNA sequences, which represent 98% of the genome, were considered an evolutionary by-product, or junk DNA. Today, however, the large families of short, untranslated ribonucleic acid sequences, such as short interfering RNA (siRNA), microRNA, rasiRNA or piRNA, revolutionize our knowledge on gene regulation. The review presents these short RNA molecules, and describes their formation and functions. The authors place special focus on the recently discovered microRNAs, a class of 21-24 nucleotides long RNA molecules that are involved in the regulation of their target's amount by annealing to the corresponding messenger RNA. The genes of microRNAs are often localized to certain fragile sites of the genome that have been described to be involved in a number of tumours. Thus, it is not surprising that after the discovery of microRNAs the relationship of altered microRNA pattern and cancer has soon become the focus of research.

Original languageHungarian
Pages (from-to)591-597
Number of pages7
JournalLege Artis Medicinae
Volume18
Issue number8-9
Publication statusPublished - Sep 2008

Fingerprint

MicroRNAs
History
Genome
RNA
Small Interfering RNA
Intergenic DNA
Research
Open Reading Frames
Genes
Neoplasms
Nucleotides
Messenger RNA
DNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nem kódoló genom és mikroRNS-ek : Új fejezet a genetika történetében. / Viktor, Molnár; Beáta, Bakos; Hegyesi, H.; Falus, A.

In: Lege Artis Medicinae, Vol. 18, No. 8-9, 09.2008, p. 591-597.

Research output: Contribution to journalArticle

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