Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior

Charles S. McManamy, Jane Pears, Claire L. Weston, Z. Hanzély, James W. Ironside, Roger E. Taylor, Richard G. Grundy, Steven C. Clifford, David W. Ellison

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Among the variants of medulloblastoma in the current WHO classification of nervous system tumors, the desmoplastic variant, which has been reported to constitute 5%-25% of pediatric medulloblastomas, is defined by its nodular collections of neurocytic cells bounded by desmoplastic internodular zones. We have studied the frequency, morphological features and biological behavior of medulloblastomas in two contemporaneous SIOP/UKCCSG trial cohorts of children with medulloblastomas, CNS9102 (n = 315) and CNS9204 (n = 35), focusing on tumors with nodular and desmoplastic phenotypes. In children aged 3-16 years (CNS9102), the nodular/desmoplastic medulloblastoma represented 5% of all tumors, while in infants aged

Original languageEnglish
Pages (from-to)151-164
Number of pages14
JournalBrain Pathology
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 2007

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Medulloblastoma
Nervous System Neoplasms
Neoplasms
Pediatrics
Phenotype

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine

Cite this

Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior. / McManamy, Charles S.; Pears, Jane; Weston, Claire L.; Hanzély, Z.; Ironside, James W.; Taylor, Roger E.; Grundy, Richard G.; Clifford, Steven C.; Ellison, David W.

In: Brain Pathology, Vol. 17, No. 2, 04.2007, p. 151-164.

Research output: Contribution to journalArticle

McManamy, CS, Pears, J, Weston, CL, Hanzély, Z, Ironside, JW, Taylor, RE, Grundy, RG, Clifford, SC & Ellison, DW 2007, 'Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior', Brain Pathology, vol. 17, no. 2, pp. 151-164. https://doi.org/10.1111/j.1750-3639.2007.00058.x
McManamy, Charles S. ; Pears, Jane ; Weston, Claire L. ; Hanzély, Z. ; Ironside, James W. ; Taylor, Roger E. ; Grundy, Richard G. ; Clifford, Steven C. ; Ellison, David W. / Nodule formation and desmoplasia in medulloblastomas - Defining the nodular/desmoplastic variant and its biological behavior. In: Brain Pathology. 2007 ; Vol. 17, No. 2. pp. 151-164.
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