Nodal-stage classification in invasive lobular breast carcinoma: Influence of different interpretations of the pTNM classification

Carolien H M Van Deurzen, G. Cserni, Simonetta Bianchi, Vania Vezzosi, Riccardo Arisio, Jelle Wesseling, Martin Asslaber, Maria P. Foschini, Anna Sapino, Isabella Castellano, Grace Callagy, Daniel Faverly, Maria Dolores Martin-Martinez, Cecily Quinn, Isabel Amendoeira, J. Kulka, Angelika Reiner-Concin, Alicia Cordoba, Cornelis A. Seldenrijk, Paul J. Van Diest

Research output: Contribution to journalArticle

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Abstract

Purpose: Application of current nodal status classification is complicated in lobular breast carcinoma metastases. The aim of this study was to define the optimal interpretation of the pTNM classification in sentinel node (SN) -positive patients to select patients with limited or with a high risk of non-SN involvement. Patients and Methods: SN metastases of 392 patients with lobular breast carcinoma were reclassified according to interpretations of the European Working Group for Breast Screening Pathology (EWGBSP) and guidelines by Turner et al, and the predictive power for non-SN involvement was assessed. Results: Reclassification according to definitions of EWGBSP and Turner et al resulted in different pN classification in 73 patients (19%). The rate of non-SN involvement in the 40 patients with isolated tumor cells according to Turner et al and with micrometastases according to EWGBSP was 20%, which is comparable to the established rate for micrometastases. The rate of non-SN involvement in the 29 patients with micrometastases according to Turner et al and with macrometastases according to EWGBSP was 48%, which is comparable to the established rate for macrometastases. Therefore, the EWGBSP method to classify SN tumor load better reflected the risk of non-SN involvement than the Turner et al system. Conclusion: Compared with the guidelines by Turner et al, the EWGBSP definitions better reflect SN metastatic tumor load and allow better differentiation between patients with lobular breast carcinoma who have a limited or a high risk of non-SN metastases. Therefore, we suggest using the EWGBSP definitions in these patients to select high-risk patients who may benefit from additional local and/or systemic therapy.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
JournalJournal of Clinical Oncology
Volume28
Issue number6
DOIs
Publication statusPublished - Feb 20 2010

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Lobular Carcinoma
Breast Neoplasms
Breast
Pathology
Neoplasm Micrometastasis
Neoplasm Metastasis
Tumor Burden
Guidelines

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Nodal-stage classification in invasive lobular breast carcinoma : Influence of different interpretations of the pTNM classification. / Van Deurzen, Carolien H M; Cserni, G.; Bianchi, Simonetta; Vezzosi, Vania; Arisio, Riccardo; Wesseling, Jelle; Asslaber, Martin; Foschini, Maria P.; Sapino, Anna; Castellano, Isabella; Callagy, Grace; Faverly, Daniel; Martin-Martinez, Maria Dolores; Quinn, Cecily; Amendoeira, Isabel; Kulka, J.; Reiner-Concin, Angelika; Cordoba, Alicia; Seldenrijk, Cornelis A.; Van Diest, Paul J.

In: Journal of Clinical Oncology, Vol. 28, No. 6, 20.02.2010, p. 999-1004.

Research output: Contribution to journalArticle

Van Deurzen, CHM, Cserni, G, Bianchi, S, Vezzosi, V, Arisio, R, Wesseling, J, Asslaber, M, Foschini, MP, Sapino, A, Castellano, I, Callagy, G, Faverly, D, Martin-Martinez, MD, Quinn, C, Amendoeira, I, Kulka, J, Reiner-Concin, A, Cordoba, A, Seldenrijk, CA & Van Diest, PJ 2010, 'Nodal-stage classification in invasive lobular breast carcinoma: Influence of different interpretations of the pTNM classification', Journal of Clinical Oncology, vol. 28, no. 6, pp. 999-1004. https://doi.org/10.1200/JCO.2009.22.0723
Van Deurzen, Carolien H M ; Cserni, G. ; Bianchi, Simonetta ; Vezzosi, Vania ; Arisio, Riccardo ; Wesseling, Jelle ; Asslaber, Martin ; Foschini, Maria P. ; Sapino, Anna ; Castellano, Isabella ; Callagy, Grace ; Faverly, Daniel ; Martin-Martinez, Maria Dolores ; Quinn, Cecily ; Amendoeira, Isabel ; Kulka, J. ; Reiner-Concin, Angelika ; Cordoba, Alicia ; Seldenrijk, Cornelis A. ; Van Diest, Paul J. / Nodal-stage classification in invasive lobular breast carcinoma : Influence of different interpretations of the pTNM classification. In: Journal of Clinical Oncology. 2010 ; Vol. 28, No. 6. pp. 999-1004.
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abstract = "Purpose: Application of current nodal status classification is complicated in lobular breast carcinoma metastases. The aim of this study was to define the optimal interpretation of the pTNM classification in sentinel node (SN) -positive patients to select patients with limited or with a high risk of non-SN involvement. Patients and Methods: SN metastases of 392 patients with lobular breast carcinoma were reclassified according to interpretations of the European Working Group for Breast Screening Pathology (EWGBSP) and guidelines by Turner et al, and the predictive power for non-SN involvement was assessed. Results: Reclassification according to definitions of EWGBSP and Turner et al resulted in different pN classification in 73 patients (19{\%}). The rate of non-SN involvement in the 40 patients with isolated tumor cells according to Turner et al and with micrometastases according to EWGBSP was 20{\%}, which is comparable to the established rate for micrometastases. The rate of non-SN involvement in the 29 patients with micrometastases according to Turner et al and with macrometastases according to EWGBSP was 48{\%}, which is comparable to the established rate for macrometastases. Therefore, the EWGBSP method to classify SN tumor load better reflected the risk of non-SN involvement than the Turner et al system. Conclusion: Compared with the guidelines by Turner et al, the EWGBSP definitions better reflect SN metastatic tumor load and allow better differentiation between patients with lobular breast carcinoma who have a limited or a high risk of non-SN metastases. Therefore, we suggest using the EWGBSP definitions in these patients to select high-risk patients who may benefit from additional local and/or systemic therapy.",
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T1 - Nodal-stage classification in invasive lobular breast carcinoma

T2 - Influence of different interpretations of the pTNM classification

AU - Van Deurzen, Carolien H M

AU - Cserni, G.

AU - Bianchi, Simonetta

AU - Vezzosi, Vania

AU - Arisio, Riccardo

AU - Wesseling, Jelle

AU - Asslaber, Martin

AU - Foschini, Maria P.

AU - Sapino, Anna

AU - Castellano, Isabella

AU - Callagy, Grace

AU - Faverly, Daniel

AU - Martin-Martinez, Maria Dolores

AU - Quinn, Cecily

AU - Amendoeira, Isabel

AU - Kulka, J.

AU - Reiner-Concin, Angelika

AU - Cordoba, Alicia

AU - Seldenrijk, Cornelis A.

AU - Van Diest, Paul J.

PY - 2010/2/20

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N2 - Purpose: Application of current nodal status classification is complicated in lobular breast carcinoma metastases. The aim of this study was to define the optimal interpretation of the pTNM classification in sentinel node (SN) -positive patients to select patients with limited or with a high risk of non-SN involvement. Patients and Methods: SN metastases of 392 patients with lobular breast carcinoma were reclassified according to interpretations of the European Working Group for Breast Screening Pathology (EWGBSP) and guidelines by Turner et al, and the predictive power for non-SN involvement was assessed. Results: Reclassification according to definitions of EWGBSP and Turner et al resulted in different pN classification in 73 patients (19%). The rate of non-SN involvement in the 40 patients with isolated tumor cells according to Turner et al and with micrometastases according to EWGBSP was 20%, which is comparable to the established rate for micrometastases. The rate of non-SN involvement in the 29 patients with micrometastases according to Turner et al and with macrometastases according to EWGBSP was 48%, which is comparable to the established rate for macrometastases. Therefore, the EWGBSP method to classify SN tumor load better reflected the risk of non-SN involvement than the Turner et al system. Conclusion: Compared with the guidelines by Turner et al, the EWGBSP definitions better reflect SN metastatic tumor load and allow better differentiation between patients with lobular breast carcinoma who have a limited or a high risk of non-SN metastases. Therefore, we suggest using the EWGBSP definitions in these patients to select high-risk patients who may benefit from additional local and/or systemic therapy.

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