NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease

Is Hungary different?

Carsten Büning, T. Molnár, F. Nagy, J. Lonovics, Renita Weltrich, Bettina Bochow, Janine Genschel, Hartmut Schmidt, Herbert Lochs

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aim: To analyse the impact of NOD2/CARD15 mutations on the clinical course of Crohn's disease patients from an eastern European country (Hungary). Methods: We investigated the prevalence of the three common NOD2/CARD15 mutations (Arg702Trp, Gly908Arg, 1007finsC) in 148 patients with Crohn's disease, 128 patients with ulcerative colitis and 208 controls recruited from the University of Szeged, Hungary. In patients with Crohn's disease, the prevalence of NOD2/CARD15 mutations was correlated to the demographical and clinical parameters. Results: In total, 32.4% of Crohn's disease patients carried at least one mutant allele within NOD2/CARD15 compared to 13.2% of patients with ulcerative colitis (P = 0.0002) and to 11.5% of controls (P

Original languageEnglish
Pages (from-to)407-411
Number of pages5
JournalWorld Journal of Gastroenterology
Volume11
Issue number3
Publication statusPublished - Jan 21 2005

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Hungary
Inflammatory Bowel Diseases
Crohn Disease
Genes
Ulcerative Colitis
Mutation
Alleles

Keywords

  • Crohn's disease
  • Mutation
  • NOD2/CARD15 gene

ASJC Scopus subject areas

  • Gastroenterology

Cite this

NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease : Is Hungary different? / Büning, Carsten; Molnár, T.; Nagy, F.; Lonovics, J.; Weltrich, Renita; Bochow, Bettina; Genschel, Janine; Schmidt, Hartmut; Lochs, Herbert.

In: World Journal of Gastroenterology, Vol. 11, No. 3, 21.01.2005, p. 407-411.

Research output: Contribution to journalArticle

Büning, C, Molnár, T, Nagy, F, Lonovics, J, Weltrich, R, Bochow, B, Genschel, J, Schmidt, H & Lochs, H 2005, 'NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?', World Journal of Gastroenterology, vol. 11, no. 3, pp. 407-411.
Büning, Carsten ; Molnár, T. ; Nagy, F. ; Lonovics, J. ; Weltrich, Renita ; Bochow, Bettina ; Genschel, Janine ; Schmidt, Hartmut ; Lochs, Herbert. / NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease : Is Hungary different?. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 3. pp. 407-411.
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