No teratogenic effect after clotrimazole therapy during pregnancy

E. Czeizel, Márta Tóth, M. Rockenbauer

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We evaluated the potential teratogenic effects of vaginal and/or topical administration of clotrimazole in the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1992). The dataset included 18,515 case pregnancies and 32,804 control pregnancies; 7.1% of case and 7.7% of control women used clotrimazole during pregnancy. Clotrimazole use was not clearly associated with an increase in the total (fetal + birth) prevalence of any congenital abnormality group. There was, however, a suggestion that clotrimazole use was associated with a decrease in the prevalence of undescended testis (prevalence odds ratio = 0.72; 95% confidence interval = 0.54-0.95).

Original languageEnglish
Pages (from-to)437-440
Number of pages4
JournalEpidemiology
Volume10
Issue number4
Publication statusPublished - Jul 1999

Fingerprint

Clotrimazole
Pregnancy
Intravaginal Administration
Topical Administration
Cryptorchidism
Therapeutics
Odds Ratio
Parturition
Confidence Intervals
Population
Datasets

Keywords

  • Case-control study
  • Clotrimazole
  • Congenital abnormalities
  • Teratogenic effect
  • Vulvovaginal candidosis

ASJC Scopus subject areas

  • Epidemiology

Cite this

No teratogenic effect after clotrimazole therapy during pregnancy. / Czeizel, E.; Tóth, Márta; Rockenbauer, M.

In: Epidemiology, Vol. 10, No. 4, 07.1999, p. 437-440.

Research output: Contribution to journalArticle

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