No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry

Herbert P. Ludewick, Sibylle G. Schwab, Margot Albus, Bernard Lerer, Wolfgang Maier, M. Trixler, Dieter B. Wildenauer

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in the trace amine associated receptor trace amine associated receptor 6 gene and 3′ flanking region have been shown to be associated with schizophrenia. To replicate these findings, we conducted a family-based association study with the five most significant SNPs in our sample of 79 sib-pair families (56/79 sib-pair families showed linkage to 6q23) and 125 triads. No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our family samples.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
JournalPsychiatric Genetics
Volume18
Issue number4
DOIs
Publication statusPublished - Aug 2008

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Amines
Single Nucleotide Polymorphism
Schizophrenia
3' Flanking Region
Population
Genes

Keywords

  • Association study
  • Family based
  • Schizophrenia
  • Trace amine associated receptor 6

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Biological Psychiatry
  • Neuroscience(all)

Cite this

No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. / Ludewick, Herbert P.; Schwab, Sibylle G.; Albus, Margot; Lerer, Bernard; Maier, Wolfgang; Trixler, M.; Wildenauer, Dieter B.

In: Psychiatric Genetics, Vol. 18, No. 4, 08.2008, p. 208-210.

Research output: Contribution to journalArticle

Ludewick, Herbert P. ; Schwab, Sibylle G. ; Albus, Margot ; Lerer, Bernard ; Maier, Wolfgang ; Trixler, M. ; Wildenauer, Dieter B. / No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry. In: Psychiatric Genetics. 2008 ; Vol. 18, No. 4. pp. 208-210.
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