No mitochondrial haplotype was found to increase risk for Alzheimer's disease

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Abstract

Background: Seventy Alzheimer's disease (AD) patients and 80 age- and sex-matched controls were analyzed for mitochondrial mutations T4336C and A3397G, reported to be associated with AD, and for mutations T4216C/G13708A characteristic for a normal human haplotype associated with increased frequency of occurrence of some hereditary diseases. The distribution of apolipoprotein E (apoE) alleles was also analyzed. Methods: Mitochondrial DNA was amplified by polymerase chain reaction, and the presence of mutations was detected by digestion with appropriately chosen restriction endonucleases (restriction fragment length polymorphism). Results: One patient and 2 controls were found to belong to the T4336C/T16304C haplotype. No A3397G mutant was detected. The T4216C/G13708A haplotype occurred at 5/70 and 5/80 frequency in the two groups. Prevalence of the apoE4 allele was significantly higher in AD patients (25%) than in the control group (8.1%). Conclusions: The T4336C/T16304C mutations were not found to be associated with AD, and no predisposing mitochondrial haplotypes were found.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalBiological Psychiatry
Volume44
Issue number5
DOIs
Publication statusPublished - Sep 1 1998

Keywords

  • Allele polymorphism
  • Apolipoprotein E4
  • Hungarian population
  • Late-onset Alzheimer's dementia
  • Mitochondrial DNA mutation
  • Mitochondrial haplotype

ASJC Scopus subject areas

  • Biological Psychiatry

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