No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study

P. Falkai, W. G. Honer, S. David, B. Bogerts, K. Majtényi, T. A. Bayer

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Schizophrenia is clinically and neuropsychologically characterized by severe cognitive and functional impairment suggesting the presence of a neurodegenerative process in the brains of affected individuals. A variety of neuroanatomical changes have been described such as loss and disorientation of neurons in grey and white matter and cortical atrophy. However, the neuropathological basis for schizophrenia is still unclear. In the present study we monitored the density of GFAP-positive astrocytes in brains of 33 schizophrenic patients and 26 healthy controls. Both grey matter (entorhinal cortex and subiculum) and white matter (premotor cortex, subventricular zone of the third ventricle and next to inferior horn) structures were measured bilaterally. The overall finding was that there is no evidence for increased astrogliosis in brains of schizophrenic patients vs healthy controls. Therefore, degeneration is unlikely to be the main neuropathological mechanism in schizophrenic brains.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalNeuropathology and Applied Neurobiology
Volume25
Issue number1
Publication statusPublished - 1999

Fingerprint

Brain
Schizophrenia
Confusion
Entorhinal Cortex
Third Ventricle
Lateral Ventricles
Motor Cortex
Horns
Astrocytes
Atrophy
Hippocampus
Neurons
White Matter
Gray Matter
Cognitive Dysfunction

Keywords

  • GFAP
  • Immunohistochemistry
  • Post-mortem
  • Schizophrenia

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study. / Falkai, P.; Honer, W. G.; David, S.; Bogerts, B.; Majtényi, K.; Bayer, T. A.

In: Neuropathology and Applied Neurobiology, Vol. 25, No. 1, 1999, p. 48-53.

Research output: Contribution to journalArticle

Falkai, P, Honer, WG, David, S, Bogerts, B, Majtényi, K & Bayer, TA 1999, 'No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study', Neuropathology and Applied Neurobiology, vol. 25, no. 1, pp. 48-53.
Falkai, P. ; Honer, W. G. ; David, S. ; Bogerts, B. ; Majtényi, K. ; Bayer, T. A. / No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study. In: Neuropathology and Applied Neurobiology. 1999 ; Vol. 25, No. 1. pp. 48-53.
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