No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples

Lili Magyari, Bernadett Faragó, Judit Bene, Katalin Horvatovich, Lilla Lakner, Márta Varga, Mária Figler, Beáta Gasztonyi, Gyula Mózsik, Béla Melegh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: The goal of the current work was to analyse the revalence of the +49A/G variant of the cytotoxic T-ly-mphocyte antigen 4 gene (CTLA4) in Hungarian patients with Crohn's disease (CD) and ulcerative colitis (UC). Methods: A total of 130 unrelated subjects with CD and 150 with UC, and 170 matched controls were genotyped for the single nucleotide polymorphism (SNP). The genotypes were determined by using PCR/RFLP test. Results: The G allele frequency and the prevalence of the GG genotype were 38.1% and 12.3% in the CD group, 40.6% and 18.6% in the UC patients, and 37.4% and 15.9% in the control group, respectively. Conclusion: The results of the current study show that carriage of the +49G SNP in heterozygous or in homozygous form does not confer risk either for CD or for UC in the Hungarian population.

Original languageEnglish
Pages (from-to)2205-2208
Number of pages4
JournalWorld journal of gastroenterology
Volume13
Issue number15
DOIs
Publication statusPublished - Apr 21 2007

Keywords

  • Crohn's disease
  • Cytotoxic T-lymphocyte antigen 4
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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