No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: A population-based case–control study

Mária Szilasi, Liza Bártfai, Zoltán Bártfai, F. Bánhidy, Andrew E. Czeizel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitamin E intake either in their diet or by taking supplements. The objective was to examine this association. The Hungarian Case–Control Surveillance System of Congenital Abnormalities, 1980–1996, is a large, population-based dataset including 22,843 cases with congenital abnormalities, 38,151 healthy controls matched to the cases, and 834 patient controls with Down syndrome. Vitamin E treatment was compared in the mothers of these children. The mothers of 1418 cases with congenital abnormalities (6.2%), 2267 controls (6.0%) and 43 patient controls (5.2%) had vitamin E treatment during pregnancy. A preliminary comparison of cases and controls showed a higher risk for four congenital abnormality groups, including cardiovascular malformations. However, if only prospectively and medically recorded vitamin E treatments in the prenatal maternity logbook were evaluated during the critical period of different congenital abnormalities, the higher risk for these congenital abnormalities was not found. The results of this study were based on relatively high-dose vitamin E intake in pregnant women and were not able to confirm the previously reported teratogenic effect of vitamin E.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalTherapeutic Advances in Drug Safety
Volume2
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • cardiovascular malformations
  • congenital abnormalities
  • population-based case–control study
  • pregnancy
  • vitamin E

ASJC Scopus subject areas

  • Pharmacology (medical)

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