No association between oxytocin or prolactin gene variants and childhood-onset mood disorders

John S. Strauss, Natalie L. Freeman, Sajid A. Shaikh, Ágnes Vetró, Eniko Kiss, Krisztina Kapornai, Gabriella Daróczi, Timea Rimay, Viola Osváth Kothencné, Edit Dombovári, Emília Kaczvinszk, Zsuzsa Tamás, Ildikó Baji, Márta Besny, Julia Gádoros, Vincenzo DeLuca, Charles J. George, Emma Dempster, Cathy L. Barr, Maria KovacsJames L. Kennedy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. In human studies, serum OXT and PRL levels have been associated with depression and related phenotypes. Our purpose was to determine if single nucleotide polymorphisms (SNPs) at the loci for OXT, PRL and their receptors, OXTR and PRLR, were associated with childhood-onset mood disorders (COMD). Methods: Using 678 families in a family-based association design, we genotyped 16 SNPs at OXT, PRL, OXTR and PRLR to test for association with COMD. Results: No significant associations were found for SNPs in the OXTR, PRL, or PRLR genes. Two of three SNPs 3' of the OXT gene were associated with COMD (p≤ 0.02), significant after spectral decomposition, but were not significant after additionally correcting for the number of genes tested. Supplementary analyses of parent-of-origin and proband sex effects for OXT SNPs by Fisher's Exact test were not significant after Bonferroni correction. Conclusions: We have examined 16 OXT and PRL system gene variants, with no evidence of statistically significant association after correction for multiple tests.

Original languageEnglish
Pages (from-to)1422-1428
Number of pages7
JournalPsychoneuroendocrinology
Volume35
Issue number9
DOIs
Publication statusPublished - Oct 1 2010

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Keywords

  • Mood disorder
  • Oxytocin
  • Prolactin
  • Single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Strauss, J. S., Freeman, N. L., Shaikh, S. A., Vetró, Á., Kiss, E., Kapornai, K., Daróczi, G., Rimay, T., Kothencné, V. O., Dombovári, E., Kaczvinszk, E., Tamás, Z., Baji, I., Besny, M., Gádoros, J., DeLuca, V., George, C. J., Dempster, E., Barr, C. L., ... Kennedy, J. L. (2010). No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. Psychoneuroendocrinology, 35(9), 1422-1428. https://doi.org/10.1016/j.psyneuen.2010.04.008