No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population

Ágnes Fehér, Anna Juhász, A. Rimanóczy, M. Pákáski, J. Kálmán, Z. Janka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Calcium homeostasis modulator 1 (CALHM1), a promising candidate gene for Alzheimer's disease risk, has been recently identified. We tested the hypothesis that the T-allelic variant of the CALHM1 rs2986017 polymorphism confers susceptibility to Alzheimer's disease in a Hungarian case-control sample that was also genotyped for apolipoprotein E. This study included 238 probable patients with Alzheimer's disease who met the diagnostic criteria for National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association and 202 elderly healthy control participants. We failed to detect an association between the CALHM1 polymorphism and the risk for Alzheimer's disease (P=0.153 for genotypes and P=0.090 for alleles), nor did we find an effect on age at onset. However, a potential weak correlation between the presence of the T allele (CT and TT genotypestogether) and Alzheimer's disease was observed (P=0.056).

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalPsychiatric Genetics
Volume21
Issue number5
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

Alzheimer Disease
Homeostasis
Calcium
Population
Alleles
National Institute of Neurological Disorders and Stroke
Communication Disorders
Apolipoproteins E
Age of Onset
Alzheimer disease type 1
Healthy Volunteers
Genotype
Genes

Keywords

  • Alzheimer's disease
  • apolipoprotein E
  • calcium homeostasis modulator 1
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population. / Fehér, Ágnes; Juhász, Anna; Rimanóczy, A.; Pákáski, M.; Kálmán, J.; Janka, Z.

In: Psychiatric Genetics, Vol. 21, No. 5, 01.01.2011, p. 249-252.

Research output: Contribution to journalArticle

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