NMR study of some diastereomeric nucleoside-3′-thiophosphate derivatives in solution

Research output: Contribution to journalArticle

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Abstract

The conformational properties of diastereomeric P-modified nucleotides are reported as reflected by different NMR parameters. Some conformational trends can be rationalized by consideration of the 3 J(C4′,P)and 3 J(C2′,P) coupling values of the isomers and the nature of the substituent on the phosphorus. Configurational assessment of the phosphorus is inferred from NOE experiments. The effects of temperature, solvent and size of substituents are presented.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalAnalytical and Bioanalytical Chemistry
Volume379
Issue number1
DOIs
Publication statusPublished - May 2004

Fingerprint

Nucleosides
Phosphorus
Nuclear magnetic resonance
Derivatives
Isomers
Nucleotides
Temperature
Experiments
thiophosphoric acid

Keywords

  • C-P coupling constants
  • Conformational properties
  • Modified nucleotides

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

NMR study of some diastereomeric nucleoside-3′-thiophosphate derivatives in solution. / Gács-Baitz, E.; Kajtár-Peredy, M.; Sági, Gyula.

In: Analytical and Bioanalytical Chemistry, Vol. 379, No. 1, 05.2004, p. 56-59.

Research output: Contribution to journalArticle

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