NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid)

Nanoparticles in solution

Z. Nagy, L. Novák, C. Kozma, M. Berka, I. Bányai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Poly(γ-glutamic acid) (γ-PGA) and its partially benzylamidated (hydrophobized) derivatives were prepared and studied in solution by means of dynamic light scattering (DLS), 1D, 2D and PGSE NMR in order to determine the structure, size and aggregation in solution. By pH potentiometric titrations in aqueous solution the apparent pK ≈ 4 of γ-PGA was determined. The measured diffusion coefficients as a function of pH showed the swelling of γ-PGA by deprotonation of carboxyls. DLS measurements showed a certain degree of aggregation even in dilute solution. The degree of aggregation is increased in the presence H2PO4- and HPO 42- buffer anions. Benzylamidation of 30-50% of caboxylates resulted in folded structure of the BzPGA, probably spherical like nanoparticles, verified by NMR diffusiometry and 2D NOE spectroscopy.

Original languageEnglish
Title of host publicationProgress in Colloid and Polymer Science
Pages200-208
Number of pages9
Volume135
DOIs
Publication statusPublished - 2008

Publication series

NameProgress in Colloid and Polymer Science
Volume135
ISSN (Print)0340255X

Fingerprint

glutamic acid
Prostaglandins A
Glutamic Acid
Nuclear magnetic resonance
Nanoparticles
nanoparticles
nuclear magnetic resonance
Agglomeration
Acids
light scattering
Dynamic light scattering
swelling
titration
Deprotonation
diffusion coefficient
buffers
Titration
anions
aqueous solutions
Anions

Keywords

  • Aggregation
  • Amphipatic polymers
  • NMR diffusiometry
  • Poly(γ-glutamic acid)
  • Self-assembly

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Nagy, Z., Novák, L., Kozma, C., Berka, M., & Bányai, I. (2008). NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid): Nanoparticles in solution. In Progress in Colloid and Polymer Science (Vol. 135, pp. 200-208). (Progress in Colloid and Polymer Science; Vol. 135). https://doi.org/10.1007/2882-2008-112

NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid) : Nanoparticles in solution. / Nagy, Z.; Novák, L.; Kozma, C.; Berka, M.; Bányai, I.

Progress in Colloid and Polymer Science. Vol. 135 2008. p. 200-208 (Progress in Colloid and Polymer Science; Vol. 135).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nagy, Z, Novák, L, Kozma, C, Berka, M & Bányai, I 2008, NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid): Nanoparticles in solution. in Progress in Colloid and Polymer Science. vol. 135, Progress in Colloid and Polymer Science, vol. 135, pp. 200-208. https://doi.org/10.1007/2882-2008-112
Nagy Z, Novák L, Kozma C, Berka M, Bányai I. NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid): Nanoparticles in solution. In Progress in Colloid and Polymer Science. Vol. 135. 2008. p. 200-208. (Progress in Colloid and Polymer Science). https://doi.org/10.1007/2882-2008-112
Nagy, Z. ; Novák, L. ; Kozma, C. ; Berka, M. ; Bányai, I. / NMR study of poly(γ-glutamic acid) and partially benzylated poly(γ-glutamic acid) : Nanoparticles in solution. Progress in Colloid and Polymer Science. Vol. 135 2008. pp. 200-208 (Progress in Colloid and Polymer Science).
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