NMR study of 6-azabicyclo[3.2.1]octene derivatives, By-products of catharanthine synthesis

Eszter Gács-Baitz, Hedvig Bölcskei, Csaba Szántay

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Abstract

The structures and stereochemistries of several 6-azabicyclo[3.2.1]octene derivatives, obtained by rearrangement reactions of the catharanthine synthesis, were determined by various NMR methods. Long-range 13C-1H coupling constants were measured by selective two-dimensional INEPT experiments. The dependence of 3J(C, H) and 2J(C, H) coupling constants on the dihedral angles and on the position of an electronegative substituent along the coupling path was studied.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number2
DOIs
Publication statusPublished - Jan 1 1994

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ASJC Scopus subject areas

  • Chemistry(all)

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