NMR studies of the inclusion complexes between ezetimibe and cyclodextrins

Hajnal Kelemen, Angella Csillag, Bela Noszal, Gabor Orgovan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ezetimibe, the antihyperlipidemic drug of poor bioavailability was complexed with native and derivatized cyclodextrins.The complexes were characterized in terms stability, stoichiometry and structure using various 1D and 2D solution NMR spectroscopic techniques. The complexes were found to be of moderate stability (logK<3). The least stable inclusion complex is formed with ?-cyclodextrin, while the ezetimibe-methylated- ?-cyclodextrin has a 7-fold higher stability. The results can be useful to improve the poor water-solubility and the concomitant bioavailability of ezetimibe.

Original languageEnglish
Pages (from-to)1838-1841
Number of pages4
JournalRevista de Chimie
Volume69
Issue number7
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Cyclodextrin
  • Ezetimibe
  • Inclusion complex
  • Job plot
  • Stoichiometry

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

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