NMR analysis, protonation equilibria and decomposition kinetics of tolperisone

Gábor Orgován, Károly Tihanyi, Béla Noszál

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The rate constants of spontaneous and hydroxide-catalyzed decomposition and the tautomer-specific protonation constants of tolperisone, a classical muscle relaxant were determined. A solution NMR method without any separation techniques was elaborated to quantitate the progress of decomposition. All the rate and equilibrium constants were determined at four different temperatures and the activation parameters were calculated. The molecular mechanism of decomposition is proposed.

Original languageEnglish
Pages (from-to)718-723
Number of pages6
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume50
Issue number5
DOIs
Publication statusPublished - Dec 5 2009

Keywords

  • Decomposition kinetics
  • Mannich base
  • Protonation constants
  • Tautomerization
  • Tolperisone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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