NMDA receptors are not involved in the MK-801-induced increase of striatal dopamine release in rat: a microdialysis study

Janos P. Kiss, Eugene Tóth, Abel Lajtha, E. Sylvester Vizi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Brain microdialysis and high-performance liquid chromatography with electrochemical detection were utilized to study the effect of the selective non-competitive NMDA antagonist MK-801 (dizocilpine) on striatal dopamine (DA) release in the anesthetized rat. Perfusion of 100 μM and 300 μM (+)-MK-801 through the probe did not significantly change the basal release of DA. These results suggest that excitatory amino acids do not exert a tonic excitatory influence on striatal DA release through NMDA receptors. 1 mM and 3 mM (±)-MK-801 caused a significant increase (398% and 580%, respectively), while there was no change in the level of dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). To clarify the mechanism of the (±)-MK-801-induced increase, the differential effect of its enantiomers (the active (+)-MK-801 and the less active (-)-MK-801 and the less active was determined. There was no difference in the action of these compounds: both drugs increased the striatal DA release with the same efficacy. Our data suggest that the MK-801-induced increase of striatal DA release is not an NMDA receptor-mediated effect.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalBrain research
Volume641
Issue number1
DOIs
Publication statusPublished - Mar 28 1994

Keywords

  • Dizocilpine
  • Dopamine
  • MK-801
  • Microdialysis
  • NMDA receptor
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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