NMDA-like receptors in the CNS of molluscs

Leonid L. Moroz, János Györi, J. Salánki

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The properties of L-glutamate sensitive neurones in the fresh-water snail Lymnaea stagnalis were studied to determine whether or not NMDA type receptors are present in molluscan ganglia. Experiments were carried out in isolated ganglia and with dialysed neurones. In the neurosecretory light yellow cells (LYC) both glutamate and NMDA (but not other glutamate agonists) induced prolonged depolarization and inward current. The sensitivity of the neurones for NMDA was lower than for glutamate. Both currents are carried by Na- and Ca-ions and have linear I-V characteristics. Mg-ions did not reduce either but glycine potentiated both glutamate and NMDA responses. It is concluded that in the molluscan central nervous system glutamate receptors have some of the characteristics of mammalian NMDA receptors.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalNeuroReport
Volume4
Issue number2
Publication statusPublished - 1993

Fingerprint

Mollusca
N-Methyl-D-Aspartate Receptors
Glutamic Acid
N-Methylaspartate
Neurons
Ganglia
Ions
Lymnaea
Excitatory Amino Acid Agonists
Snails
Glutamate Receptors
Fresh Water
Glycine
Central Nervous System

Keywords

  • Cat-ionic channels
  • Dialysed neurone
  • Glycin
  • L-glutamate
  • Lymnaea stagnalis
  • Molluscs
  • NMDA-receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Moroz, L. L., Györi, J., & Salánki, J. (1993). NMDA-like receptors in the CNS of molluscs. NeuroReport, 4(2), 201-204.

NMDA-like receptors in the CNS of molluscs. / Moroz, Leonid L.; Györi, János; Salánki, J.

In: NeuroReport, Vol. 4, No. 2, 1993, p. 201-204.

Research output: Contribution to journalArticle

Moroz, LL, Györi, J & Salánki, J 1993, 'NMDA-like receptors in the CNS of molluscs', NeuroReport, vol. 4, no. 2, pp. 201-204.
Moroz, Leonid L. ; Györi, János ; Salánki, J. / NMDA-like receptors in the CNS of molluscs. In: NeuroReport. 1993 ; Vol. 4, No. 2. pp. 201-204.
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