NK1 and NK2 receptors contribute to C-fibre evoked slow potentials in the spinal cord

Istvan Nagy, Barbara A. Miller, Clifford J. Woolf

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Small diameter primary afferent; produce slow synaptic potentials in spinal neurones. These can be recorded as prolonged ventral root potentials (VRPs) in the isolated neonatal rat spinal cord preparation. The VRP elicited by stimulating C-fibres consists of two phases: An early phase comprising a monosynaptic and a short polysynaptic response identical to that elicited by low threshold Aβ fibres and a late phase which has an initial component (0.1-1 s) which is sensitive to N-methyl-D-aspartic acid receptor antagonism and a very long lasting second component (1-20 s) which is resistant to these antagonists. We now demonstrate that the slowest component of the VRP is significantly reduced by both NK, and NK2 tachykinin receptor antagonists and as a consequence, tachykinins have a particular contribution to the cumulative depolarization produced by low frequency (1 Hz) C-fibre stimulation.

Original languageEnglish
Pages (from-to)2105-2108
Number of pages4
JournalNeuroreport
Volume5
Issue number16
DOIs
Publication statusPublished - Oct 1994

Keywords

  • C-fibres
  • Neurokinin receptors
  • Pain
  • Slow synaptic potentials
  • Substance P
  • Tachykinins

ASJC Scopus subject areas

  • Neuroscience(all)

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