NK1 receptor expression by cholinergic interneurones in human striatum

Jean Michel Aubry, Kenneth Lundström, Eric Kawashima, Guidon Ayala, Pierre Schulz, Viktor Bartanusz, J. Kiss

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Neurokinin-1 (NK1) receptor expression in human striatum was analysed using the polymerase chain reaction. To determine whether cholinergic interneurones express this receptor, in situ hybridization histochemistry was then applied to caudate nucleus and putamen. Radioactive oligonucleotide probes specific for choline acetyltransferase (ChAT) and NK1 receptor mRNA were used on adjacent cryostat sections. All of the 160 identified neurones positive for ChAT were also labelled for NK1 receptor. Moreover, in the caudate nucleus, NK1 receptor mRNA was detected in a population of large neurones that were not cholinergic. These results are consistent with the hypothesis that NK1 receptor-mediated mechanisms are involved in the function of cholinergic interneurones. This might be relevant to pharmacological or pathophysiological situations where substance P inputs are modified.

Original languageEnglish
Pages (from-to)1597-1600
Number of pages4
JournalNeuroReport
Volume5
Issue number13
Publication statusPublished - 1994

Fingerprint

Neurokinin-1 Receptors
Interneurons
Cholinergic Agents
Choline O-Acetyltransferase
Caudate Nucleus
Neurons
Messenger RNA
Oligonucleotide Probes
Putamen
Substance P
In Situ Hybridization
Pharmacology
Polymerase Chain Reaction
Population

Keywords

  • Choline acetyltransferase
  • In situ hybridization
  • Interneurone
  • mRNA
  • NK1 receptor
  • Polymerase chain reaction
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Aubry, J. M., Lundström, K., Kawashima, E., Ayala, G., Schulz, P., Bartanusz, V., & Kiss, J. (1994). NK1 receptor expression by cholinergic interneurones in human striatum. NeuroReport, 5(13), 1597-1600.

NK1 receptor expression by cholinergic interneurones in human striatum. / Aubry, Jean Michel; Lundström, Kenneth; Kawashima, Eric; Ayala, Guidon; Schulz, Pierre; Bartanusz, Viktor; Kiss, J.

In: NeuroReport, Vol. 5, No. 13, 1994, p. 1597-1600.

Research output: Contribution to journalArticle

Aubry, JM, Lundström, K, Kawashima, E, Ayala, G, Schulz, P, Bartanusz, V & Kiss, J 1994, 'NK1 receptor expression by cholinergic interneurones in human striatum', NeuroReport, vol. 5, no. 13, pp. 1597-1600.
Aubry JM, Lundström K, Kawashima E, Ayala G, Schulz P, Bartanusz V et al. NK1 receptor expression by cholinergic interneurones in human striatum. NeuroReport. 1994;5(13):1597-1600.
Aubry, Jean Michel ; Lundström, Kenneth ; Kawashima, Eric ; Ayala, Guidon ; Schulz, Pierre ; Bartanusz, Viktor ; Kiss, J. / NK1 receptor expression by cholinergic interneurones in human striatum. In: NeuroReport. 1994 ; Vol. 5, No. 13. pp. 1597-1600.
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