2-(2-Pyridylaminomethylene)succinates, which in ethanolic sodium ethoxide solution yielded equilibrium mixtures of the pyridopyrimidines (3) and the pyridyldihydropyrrolones (5) and (6), within 15 min, furnished a dihydropyrrolone dimer as the main product on longer (≥2 h) reaction. The dimer had the unusual 4,4'-connection between the five-membered rings, and was shown to be the pure transdiastereoisomer (7); it is considered to be formed by a Michael addition reaction of the pyrrolones (5) and (6). These longer reactions are accompanied by hydrolytic processes.
|Number of pages||4|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - Jan 1 1988|
ASJC Scopus subject areas