Nitric oxide modulates the gastrointestinal plasma extravasation following intraabdominal surgical manipulation in rats

Ferenc László, Éva Morschl, Imre Pávó, Brendan J.R. Whittle

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6 Citations (Scopus)


The actions of nitric oxide (NO) on gastrointestinal plasma loss, assessed by the leakage of [125I]human serum albumin, provoked by intraabdominal surgery and organ manipulation has been investigated in pentobarbitone-anaesthesized rats. Gentle manipulation (3 min) of the stomach or the small intestine following laparotomy leads to an increase in albumin extravasation in the stomach, duodenum, jejunum and colon over 1 h. Administration of the NO synthase inhibitors, N(G)-nitro-L-arginine methyl ester (1-5 mg kg-1, s.c.) and N(G)-monomethyl-L-arginine (12.5-50 mg kg-1, s.c.), provoked a further substantial elevation of gastrointestinal albumin extravasation in the surgically manipulated rat, but not in control rats. This effect could be prevented by the pretreatment (15 min) with L-arginine (300 mg kg-1, s.c.) or by the concurrent infusion of the NO donor, S-nitroso-glutathione (5 μg kg-1 min-1, i.v.). Endogenous NO, most likely formed by endothelial NO synthase, thus appears to maintain microvascular integrity during surgery and organ manipulation of the gastrointestinal tract. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)211-215
Number of pages5
JournalEuropean Journal of Pharmacology
Issue number1-3
Publication statusPublished - Jun 30 1999



  • Gastrointestinal tract
  • Microcirculation
  • Nitric oxide (NO) endothelial
  • Plasma loss
  • Surgery
  • Vascular permeability

ASJC Scopus subject areas

  • Pharmacology

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