Nitric oxide-mediated mucus hypersecretion protects the stomach of ovariectomized rats

Éva Morschl, Ildikó Bretus, Imre Pávó, Lajos Topa, Zsóka Weiszhar, Ferenc László

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Abstract

The actions of ovariectomy on nitric oxide synthase (assessed by the citrullin assay), mucus secretion (assessed by the Alcyan blue technique) and ulcerogenic response (indomethacin (30 mg kg-1, s.c., 4 h) or cysteamine (400 mg kg-1, s.c., 24 h)) were studied in the female rat stomach. Ovariectomy increased nitric oxide synthase and mucus secretion, and decreased the severity of lesions, effects reversed by the nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME, 10 mg kg-1, s.c., 4 h before measurements). Therefore, estrogen-deficiency protects the gastric mucosa by nitric oxide (NO)-mediated mucus hypersecretion. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)R5-R7
JournalEuropean Journal of Pharmacology
Volume392
Issue number1-2
DOIs
Publication statusPublished - Mar 24 2000

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Keywords

  • Estrogen
  • Gastric mucus
  • Nitric oxide (NO)

ASJC Scopus subject areas

  • Pharmacology

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