Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine

Lorand Barthó, Romain Lefebvre

Research output: Contribution to journalArticle

29 Citations (Scopus)


In longitudinal muscle/myenteric plexus preparations of the guinea-pig ileum, exogenous nitric oxide (NO) induced concentration-dependent relaxations. In tissues at basal tone, NO (3 × 10-6 M) induced a moderate relaxation followed by a pronounced contraction, consisting of a quick and sustained component. Tetrodotoxin (5 × 10-7 M) abolished both phases of the contraction. Atropine (5 × 10-7 M) abolished the quick component and reduced the sustained component of the contraction; the latter was further suppressed by the selective NK1 receptor antagonist CP 96,345. Hexamethonium (5 × 10-5 M) failed to affect the contractile response to NO. It is concluded that administration of exogenous NO in the guinea-pig ileum can lead to activation cholinergic and to a lesser degree tachykininergic neurones.

Original languageEnglish
Pages (from-to)582-584
Number of pages3
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number5
Publication statusPublished - Nov 1 1994


  • Acetylcholine
  • Contraction
  • Guinea-pig ileum
  • Nitric oxide
  • Substance P

ASJC Scopus subject areas

  • Pharmacology

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