Nitric oxide in IgA nephropathy patients with or without hypertension

T. Kovacs, J. Barta, B. Kocsis, J. Nagy

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7 Citations (Scopus)

Abstract

Nitric oxide (NO) is claimed to have a role in the pathogenesis of immune mediated glomerulonephritis and in the regulation of blood pressure (BP). NO rapidly converts to NO2-/NO3- which is excreted in the urine. We determined the daily NO2-/NO3- excretion in 26 IgA nephropathy (NP) patients and 20 healthy controls, recording the BP in each. There was no difference in NO2-/NO3- excretion between IgA NP patients and controls (999.1 ± 66.8 vs. 1,051.2 ± 53.0 μmol/day). The urinary excretion of NO2-/NO3- in IgA NP patients whose mean diastolic BP remained above 85 mm Hg in spite of antihypertensive therapy, was significantly decreased (n = 8; 734.38 ± 87.83 μmol/day; p < 0.05). There was a significant inverse correlation between mean diastolic BP and urinary NO2-/NO3- (p < 0.006). NO2-/NO3- excretion decreased with aging (p < 0.01) in IgA NP patients, but not in controls. The fact that there was no difference between the urinary NO2-/NO3- excretion of IgA NP patients and controls argues against the idea that NO production in immune mediated IgA NP can be increased. The decrease of urinary NO2-/ NO3- in hypertensive and in older IgA NP patients may be correlated with the impaired NO production of the endothelium.

Original languageEnglish
Pages (from-to)369-372
Number of pages4
JournalExperimental nephrology
Volume3
Issue number6
Publication statusPublished - Jan 1 1995

Keywords

  • Hypertension
  • IgA nephropathy
  • Nitric oxide
  • Urinary nitrite/nitrate

ASJC Scopus subject areas

  • Nephrology

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