The effect of authentic nitric oxide (NO) was investigated on rat ileal myenteric plexus-longitudinal muscle strips in the presence of atropine. NO (10-10 to 3 × 10-6M) caused a quick, transient contraction of the smooth muscle, with an optimum concentration of 10-7M, as well as a slower contraction with a higher optimum concentration. In preparations sub-maximally pre-contracted with 5-hydroxytryptamine, NO (10-7 to 3 × 10-6M) also caused a quick relaxant response. These responses to NO (10-6M) were not influenced by tetrodotoxin, indicating a direct effect on the smooth muscle.
- NANC (non-adrenergic, non-cholinergic) neurotransmission
- Nitric oxide (NO)
- Nitric oxide (NO)-induced contraction
- Small intestine, rat
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