Nitric oxide and ATP co-mediate the NANC relaxant response in the guinea-pig taenia caeci

L. Barthó, L. Lénárd, R. Szigeti

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effect of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine (L-NOARG; 100 μM) and the P2 purinoceptor antagonist pyridoxalphosphate-6- azophenyl-2',4'-disulfonic acid (PPADS; 50 μM) was investigated on the non- adrenergic, non-cholinergic (NANC) relaxant response of the guinea-pig isolated taenia caeci to electrical field stimulation at 1 or 10 Hz, under isotonic recording conditions. Either drug alone caused an about 50% inhibition, while combining the two drugs nearly abolished the response at both frequencies. The inhibitory effect of L-NOARG (100 μM) was partly reversed by L-arginine (30 mM). PPADS, but not L-NOARG, inhibited the relaxant effect of exogenous ATP, but not that of the nitric oxide donor sodium nitroprusside. It is concluded that both nitric oxide and ATP are involved in the mediation of NANC relaxation in the taenia caeci, in an apparently additive manner.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume358
Issue number4
DOIs
Publication statusPublished - Oct 26 1998

Keywords

  • N(G) -nitro-L-arginine
  • Nitric oxide
  • P purinoceptors
  • PPADS
  • Taenia caeci (guinea-pig)

ASJC Scopus subject areas

  • Pharmacology

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