Nitric oxide activates an iberiotoxin-sensitive potassium channel in human saphenous vein

J. Höhn, J. Pataricza, G. K. Tóth, Á Balogh, J. Gy Papp

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Abstract

Synthetic iberiotoxin (IBTX), an inhibitor of large conductance calcium-activated potassium channel (BKCa), was used to study the possible involvement of a specific hyperpolarizing ion channel in nitric oxide (NO)-induced venodilation. Serotonin (0.125 μM)-induced contraction of isolated human saphenous vein was dose-dependently relaxed with 50-1550 nanoM exogenous NO. 30 min preincubation of venous preparations with 90 nanoM IBTX decreased vasorelaxation induced by NO. In conclusion, a hyperpolarizing potassium channel, BKCa, may be involved in the venodilator effect of endogenous NO.

Original languageEnglish
Pages (from-to)293-294
Number of pages2
JournalActa physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - Dec 1 1996

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Keywords

  • Human
  • Iberiotoxin
  • Nitric oxide
  • Saphenous vein

ASJC Scopus subject areas

  • Physiology (medical)

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