Nicotinic acetylcholine receptor antagonist effect of fluoxetine in rat hippocampal slices

Esteban C P Hennings, Janos P. Kiss, E. Vízi

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 μM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose- dependent manner (IC50 = 0.19 μM). The selective serotonin reuptake inhibitor (SSRI) fluoxetine also antagonised the response to nicotine in a dose-dependent manner with a similar strength (IC50 = 0.57 μM). Our data indicate that fluoxetine has nicotinic acetylcholine receptor antagonist effect in the central nervous system. The possible clinical significance of this finding is discussed.

Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalBrain Research
Volume759
Issue number2
DOIs
Publication statusPublished - Jun 6 1997

Fingerprint

Fluoxetine
Nicotinic Receptors
Cholinergic Antagonists
Mecamylamine
Nicotine
Inhibitory Concentration 50
Norepinephrine
Nicotinic Antagonists
Serotonin Uptake Inhibitors
Central Nervous System

Keywords

  • Fluoxetine
  • Hippocampus
  • Nicotine
  • Nicotinic acetylcholine receptor
  • Noradrenaline release

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Nicotinic acetylcholine receptor antagonist effect of fluoxetine in rat hippocampal slices. / Hennings, Esteban C P; Kiss, Janos P.; Vízi, E.

In: Brain Research, Vol. 759, No. 2, 06.06.1997, p. 292-294.

Research output: Contribution to journalArticle

Hennings, Esteban C P ; Kiss, Janos P. ; Vízi, E. / Nicotinic acetylcholine receptor antagonist effect of fluoxetine in rat hippocampal slices. In: Brain Research. 1997 ; Vol. 759, No. 2. pp. 292-294.
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